Publication: The Nutrition in Early Life and Asthma (NELA) birth cohortstudy: Rationale, design, and methods
Authors
Morales Bartolome, Eva ; Alcantara Lopez, Maria V. ; Cabezas Herrera, Juan ; Jimenez Guerrero, Pedro ; Larque Daza, Elvira ; Lopez Soler, Concepción ; Martinez Gracia, Carmen ; Martinez Torres, Antonela ; Mendiola Olivares, Jaime ; Nieto Diaz, Anibal ; Perez Fernandez, Virginia ; Prieto Sanchez, M. Teresa ; Salvador Garcia, Carmen ; Sanchez Solis De Querol, Manuel ; Torres Cantero, Alberto ; Yagüe, Genoveva ; Zornoza Moreno, Matilde ; Garcia-marcos Alvarez, Luis ; Santaella-Pascual, Marina ; Diego Puente, Teresa de ; Hernández Caselles, Trinidad ; Martín-Orozco Santiago, María Elena ; Noguera Velasco, José Antonio ; Sola Martínez, Rosa Alba
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DOI
https://doi.org/10.1111/ppe.12826
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info:eu-repo/semantics/article
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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in
any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
© 2021 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd.
Background: Primary prevention strategies for asthma are lacking. Its inception probably starts in utero and/or during the early postnatal period as the developmental origins of health and disease (DOHaD) paradigm suggests. Objectives: The main objective of Nutrition in Early Life and Asthma (NELA) cohort study is to unravel whether the following factors contribute causally to the developmental origins of asthma: (1) maternal obesity/adiposity and foetal growth; (2) maternal and child nutrition; (3) outdoor air pollution; (4) endocrine disruptors; and (5) maternal psychological stress. Maternal and offspring biological samples are used to assess changes in offspring microbiome, immune system, epigenome and volatilome as potential mechanisms influencing disease susceptibility. Population: Randomly selected pregnant women from three health areas of Murcia, a south-eastern Mediterranean region of Spain, who fulfilled the inclusion criteria were invited to participate at the time of the follow-up visit for routine foetal anatomy scan at 19–22 weeks of gestation, at the Maternal-Fetal Medicine Unit of the “Virgen de la Arrixaca” University Clinical Hospital over a 36-month period, from March 2015 to April 2018. Design: Prospective, population-based, maternal-child, birth cohort study. Methods: Questionnaires on exposures and outcome variables were administered to mothers at 20–24 gestation week; 32–36 gestation week; and delivery. Children were
Background: Primary prevention strategies for asthma are lacking. Its inception probably starts in utero and/or during the early postnatal period as the developmental origins of health and disease (DOHaD) paradigm suggests. Objectives: The main objective of Nutrition in Early Life and Asthma (NELA) cohort study is to unravel whether the following factors contribute causally to the developmental origins of asthma: (1) maternal obesity/adiposity and foetal growth; (2) maternal and child nutrition; (3) outdoor air pollution; (4) endocrine disruptors; and (5) maternal psychological stress. Maternal and offspring biological samples are used to assess changes in offspring microbiome, immune system, epigenome and volatilome as potential mechanisms influencing disease susceptibility. Population: Randomly selected pregnant women from three health areas of Murcia, a south-eastern Mediterranean region of Spain, who fulfilled the inclusion criteria were invited to participate at the time of the follow-up visit for routine foetal anatomy scan at 19–22 weeks of gestation, at the Maternal-Fetal Medicine Unit of the “Virgen de la Arrixaca” University Clinical Hospital over a 36-month period, from March 2015 to April 2018. Design: Prospective, population-based, maternal-child, birth cohort study. Methods: Questionnaires on exposures and outcome variables were administered to mothers at 20–24 gestation week; 32–36 gestation week; and delivery. Children were
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Paediatric and Perinatal Epidemiology, 2021;00:1–15.
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