Santaella-Pascual, Marina

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Santaella-Pascual, Marina

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Santaella-Pascual, Marina

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Universidad de Murcia. Departamento de Tecnología de los Alimentos,Nutrición y Bromatología

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Open Access
Comparison of bioavailability and transporters gene expression of four iron fortificants added to infant cereals
(Elsevier, 2022-09-08) Caballero Valcárcel, Ana M.; López Nicolás, Rubén; Frontela Saseta, María del Carmen; González Bermúdez, Carlos A.; Martínez Gracia, Carmen; Santaella-Pascual, Marina; Tecnología de Alimentos, Nutrición y Bromatología
Iron deficiency is one of the most important nutritional disorders around the world. To reduce this health problem in infants, most countries have developed different iron fortification programs as a long-term strategy. However, it is necessary to select the best iron source to get the highest bioavailability with the lowest impact on the organoleptic properties of the foods. The aim of this research was to assess the in vitro bioavailability and intestinal cellular transport of four iron sources (electrolytic iron: EI, ferrous fumarate: FF, a micronized and dispersible ferric pyrophosphate: MDFP, and ferrous sulphate heptahydrated: FSH) used to fortify infant cereals. Fortified cereals were in vitro digested and soluble fractions were then incubated in Caco-2 cells to study iron retention, transport and uptake. Moreover, mRNA expression of iron transporters and ferritin formation were also measured in cells incubated with the iron standard salts. Iron solubility, uptake percentage, transport and uptake efficiencies by the Caco-2 cells were significantly higher in cereals fortified with FSH than with EI, obtaining intermediate values for the other two iron fortificants. MDFP induced higher expression of iron transporters Zip-14 and HEPH than other iron sources. FSH promoted the highest iron storage protein ferritin, followed by FF and MDFP, while EI presented the lowest in vitro bioavailability due to its low solubility. This work demonstrated that iron absorption, storage, and gene expression of transporters depend on the source of iron. These are important challenges to be taken into consideration when assessing the potential of iron fortificants.
Open Access
Self-reported DHA supplementation during pregnancy and its association with obesity or gestational diabetes in relation to DHA concentration in cord and maternal plasma: results from NELA, a prospective mother-offspring cohort.
(2021-03) Gázquez, Antonio; Giménez-Bañón, María J.; Prieto-Sánchez, Maria T.; Martínez-Graciá, Carmen; Suárez, Clara; Morales, Eva; García-Marcos, Luis; Larqué, Elvira; Galdo-Castiñeira, Lina; Ballesteros-Meseguer, Carmen; Vioque, Jesús; Santaella-Pascual, Marina; Avilés Plaza, Francisco Valeriano; Martínez Villanueva, Miriam; Noguera Velasco, José Antonio; Cirugía, Pediatría y Obstetricia y Ginecología; Fisiología; Tecnología de Alimentos, Nutrición y Bromatología
Maternal supplementation of docosahexaenoic acid (DHA) during pregnancy has been recommended due to its role in infant development, but its effect on materno-fetal DHA status is not well established. We evaluated the associations between DHA supplementation in pregnant women with obesity or gestational diabetes mellitus (GDM) and maternal and neonatal DHA status. Serum fatty acids (FA) were analyzed in 641 pregnant women (24 weeks of gestation) and in 345 venous and 166 arterial cord blood samples of participants of the NELA cohort. Obese women (n = 47) presented lower DHA in serum than those lean (n = 397) or overweight (n = 116) before pregnancy. Linoleic acid in arterial cord was elevated in obese women, which indicates lower fetal retention. Maternal DHA supplementation (200 mg/d) during pregnancy was associated with enhanced maternal and fetal DHA levels regardless of pre-pregnancy body mass index (BMI), although higher arterial DHA in overweight women indicated an attenuated response. Maternal DHA supplementation was not associated with cord venous DHA in neonates of mothers with GDM. The cord arteriovenous difference was similar for DHA between GDM and controls. In conclusion, maternal DHA supplementation during pregnancy enhanced fetal DHA status regardless of the pre-pregnancy BMI while GDM may reduce the effect of DHA supplementation in newborns.
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Nuevas presentaciones comerciales de dorada (sparus aurata L.) de Acuicultura: evaluación de la calidad y seguridad alimentaria / Marina Santaella Pascual; directoras, Mª Jesús Periago Castón, Carmen Martínez Graciá.
(Murcia : Universidad de Murcia, Departamento de Tecnología de Alimentos, Nutrición y Bromatología,, 2011) Santaella-Pascual, Marina
Open Access
Comunicaciones Orales.-Cambios en la microbiota intestinal tras un periodo de repleción con diferentes suplementos de hierro en lechones destetados
(2020-05-27) Ana María Caballero Valcárcel; Martínez Miró, Silvia; Orengo Femenia, Juan; Madrid Sánchez, Josefa; Hernández Ruipérez, Fuensanta; Martínez-Graciá, C.; Santaella-Pascual, Marina; Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Tecnología de Alimentos, Nutrición y Bromatología; Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Producción Animal
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Urinary concentrations of non-essential and essential elements during weaning in infants from the NELA cohort in Spain
(Elsevier, 2024-09-13) Notario-Barandiaran, Leyre; Morales Bartolomé, Eva; Vioque, Jesús; Martínez Gracia, Carmen; Santaella-Pascual, Marina; Suárez Martínez, Clara; García-Marcos Álvarez, Luis Vicente; Karagas, Margaret R.; Signes-Pastor, Antonio J.; NELA Study Group; Tecnología de Alimentos, Nutrición y Bromatología; Facultad de Veterinaria
Infancy is a period of continuous growth and development, where inadequate intake of essential elements and exposure to non-essential elements may have lifelong health consequences. Thus, the aim of this study is to evaluate the urine concentration of essential and non-essential elements as a proxy for internal exposure during the weaning period, from 3 to 18 months of age. The Nutrition in Early Life and Asthma (NELA) birth cohort generated the data for this study. Sociodemographic, dietary, and urine concentration of essential (Co, Cu, Mo, I, Fe, Mn, Se, Zn, and Ni) and non-essential elements (Al, V, As, Cd, Sb, Tl, and Pb) data were available for 490 participants at 3 months of age and 216 participants at 18 months of age. Paired urine samples at both time periods were available for 175 infants. At 3 months of age, exclusively breastfed infants had lower urine concentrations of Al, V, Fe, Co, Se, Sb, and Tl. Notably, the concentration of Mo had a median (IQR) of 0.60 (0.40–2.10) μg/L compared to a median (IQR) of 39.80 (25.00–56.40) μg/L observed in infants exclusively fed with formula. When we analyzed the change in urine elements concentrations between 3 and 18 months of age, we observed increased As (0.75 vs. 18.60 μg/L), Co (0.05 vs. 0.24 μg/L), Mo (1.98 vs. 50.0 μg/L), Pb (0.15 vs. 0.69 μg/L), Se (11.3 vs. 23.1 μg/L), Tl (0.02 vs. 0.11 μg/L), and V (0.05 vs. 0.11 μg/L). For Cu, lower urine concentrations were observed at 18 months of age in comparison with concentrations at 3 months (5.77 vs. 4.41 μg/L). Among the main food items identified as driving the changes in urine concentration between 3 and 18 months of age were white fish, rice and pasta, potato chips, custard, small blue fish, and legumes. Exclusively breastfed infants showed lower exposure to non-essential elements compared to those who were fed with a mixture or formula. With the introduction of solid foods, the exposure to some non-essential elements increased drastically, as in the case of As and Pb. In addition, exposure to the essential metal Mo also increased substantially with the introduction of solid food.
Open Access
Iron bioavailability of four iron sources used to fortify infant cereals, using anemic weaning pigs as a model
Caballero-Valcarcel, A; Martinez-Gracia, C; Martinez-Miro, S; Madrid-Sanchez, J; Gonzalez-Bermudez, CA; Domenech-Asensi, G; Lopez-Nicolas, R; Santaella-Pascual, Marina; Enfermería
Purpose Iron (Fe) deficiency anemia in young children is a global health concern which can be reduced by Fe fortification of foods. Cereal is often one of the first foods given to infants, providing adequate quantities of Fe during weaning. In this work, we have compared iron bioavailability and iron status of four iron sources used to fortify infant cereals, employing piglets as an animal model. Method The study was conducted on 36 piglets, 30 of them with induced anemia. From day 28 of life, the weaned piglets were fed with four experimental diets (n=6) each fortified with 120mg Fe/kg by ferrous sulfate heptahydrate (FSH), electrolytic iron (EI), ferrous fumarate (FF), or micronized dispersible ferric pyrophosphate (MDFP) for another 21days. In addition, one group of six anemic piglets fed with the basal diet with no iron added (Control-) and a Control+ group of non-anemic piglets (n=6) were also studied. Blood indicators of iron status were measured after depletion and during the repletion period. The Fe content in organs, hemoglobin regeneration efficiency, and relative bioavailability (RBV) was also determined. Results The Fe salts adequately treated anemia in the piglets, allowing the animals to recover from the anemic state, although EI was less efficient with regard to replenishing Fe stores giving lower concentrations of plasma ferritin and iron in the spleen, liver, lung, and kidney. In addition, the RBV of EI was 88.27% with respect to the reference iron salt (FSH). Conclusions Ferrous fumarate and MDFP were equally as bioavailable as the reference salt, and were used significantly better than EI in piglets. These results contribute to extend the evidence-based results for recommending the most suitable fortificant for infant cereals.
Open Access
Ameliorative Effect of Spinach on Non-Alcoholic Fatty Liver Disease Induced in Rats by a High-Fat Diet
(MDPI, 2019-04-03) Periago-Castón, Mª Jesús; Elvira-Torales, Laura Inés; Navarro-González, Inmaculada; Pallarés, Francisco José; García-Alonso, Javier; Sevilla, Ángel; González-Barrio, Rocío; Santaella-Pascual, Marina; Tecnología de Alimentos, Nutrición y Bromatología
The purpose of this work was to evaluate the effect of dietary carotenoids from spinach on the inflammation and oxidative stress biomarkers, liver lipid profile, and liver transcriptomic and metabolomics profiles in Sprague–Dawley rats with steatosis induced by a high-fat diet. Two concentrations of spinach powder (2.5 and 5%) were used in two types of diet: high-fat (H) and standard (N). Although rats fed diet H showed an accumulation of fat in hepatocytes, they did not show differences in the values of adiponectin, tumor necrosis factor alpha (TNF- ), and oxygen radical absorption (ORAC) in plasma or of isoprostanes in urine compared with animals fed diet N. The consumption of spinach and the accumulation of and carotenes and lutein in the liver was inversely correlated with serum total cholesterol and glucose and the content of hepatic cholesterol, increasing monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA) and reducing cholesterol in the livers of rats fed diet H and spinach. In addition, changes in the expression of genes related to the fatty liver condition occurred, and the expression of genes involved in the metabolism of fatty acids and cholesterol increased, mainly through the overexpression of peroxisome proliferator activated receptors (PPARs). Related to liver metabolites, animals fed with diet H showed hypoaminoacidemia, mainly for the glucogenic aminoacids. Although no changes were observed in inflammation and oxidative stress biomarkers, the consumption of spinach modulated the lipid metabolism in liver, which must be taken into consideration during the dietary treatment of steatosis.
Open Access
Evaluación sensorial de diferentes presentaciones comerciales de dorada (Sparus Aurata L.) de acuicultura
(2012) Martínez Gracia, Carmen; Periago Castón, María Jesús; Santaella, J.; Santaella-Pascual, Marina
El análisis o evaluación sensorial, se puede definir como el análisis de los alimentos a través de los sentidos. Desde la antigüedad se ha utilizado la valoración sensorial para aceptar o rechazar los alimentos, así como para asignarle un determinado valor comercial. El análisis sensorial presenta dos grandes ventajas: la rapidez y la sencillez, sin embargo, las sensaciones que motivan al rechazo o aceptación varían con el tiempo y el momento que se perciben, dependiendo tanto de la persona como del entorno, con lo que es necesario objetivar y normalizar los términos y las condiciones que puedan influir en las determinaciones. En el presente estudio se llevó a cabo el análisis sensorial de cuatro presentaciones diferentes de dorada almacenadas en hielo: enteras, fileteadas, fileteadas y envasadas al vacío, y marinadas con zumo de limón y envasadas al vacío. El estudio se realizó para determinar el momento en el cual los distintos tipos de muestras eran rechazadas organolépticamente. Para ello un panel de catadores semientrenados evaluaron los atributos de apariencia, olor, flavor y textura, en los filetes de dorada cocinados, utilizando una escala puntuada. En las cuatro presentaciones comerciales, las puntuaciones otorgadas por el panel para la frescura decrecen linealmente a medida que pasan los días de permanencia en hielo. Los miembros del panel de catadores consideraron organolépticamente inaceptables las doradas enteras, las fileteadas y las fileteadas al vacío, en el día 22 de almacenamiento en hielo, sin embargo, las doradas marinadas no alcanzaron esta consideración en los 22 días que duró el estudio.
Open Access
Adherence to the Mediterranean Diet and Determinants Among Pregnant Women: The NELA Cohort
(MDPI, 2021-04) Suárez-Martíne z, C; Yagüe-Guirao, G; Peso-Echarri, P; Vioque, J; Morales, E; García-Marcos, L; Martínez-Graciá, C; Nela Study Group, .; Santaella-Pascual, Marina; Genética y Microbiología
La dieta mediterránea representa uno de los patrones dietéticos más estudiados; sin embargo, no existe una herramienta única para medir el grado de adherencia ni un conjunto único de criterios para adaptar estos índices a las mujeres embarazadas. Caracterizamos la adherencia a la dieta mediterránea (MDA) de las mujeres embarazadas que participaron en la cohorte NELA (Nutrition in Early Life and Asthma) e identificamos los determinantes sociodemográficos y los hábitos de estilo de vida asociados con un mayor riesgo de una MDA baja. La dieta materna durante la gestación se evaluó mediante un Cuestionario de Frecuencia Alimentaria (FFQ) validado (n = 665). Estimamos la puntuación de la Dieta Mediterránea Relativa (rMED), la puntuación de la Dieta Mediterránea Alternativa (aMED) y el Índice Alternativo de Alimentación Saludable-2010 (AHEI-2010). Se realizaron modelos de regresión multivariados para identificar los factores sociodemográficos y de estilo de vida asociados a cada índice. Las madres con menor edad y más partos previos tuvieron mayor probabilidad de MDA baja (p < 0,05). Sólo para el índice aMED, las madres con formación universitaria y/o que practicaban actividades deportivas durante dos o más horas semanales tuvieron menor probabilidad de tener una MDA baja (p < 0,01). Los tres índices clasificaron a la cohorte NELA como de nivel medio de adherencia. Estos resultados pueden mejorarse mediante el diseño de estrategias de intervención y recomendaciones dietéticas para la salud tanto materna como infantil.
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Effect of the addition of tomato paste on the nutritional and sensory properties of mortadella
(Elsevier, 2012-08-27) Doménech Asensi, Guillermo; García Alonso, F.J.; MartÍnez, E.; Martín Pozuelo, G.; Bravo, S.; Periago Caston, M.J.; Santaella-Pascual, Marina; Enfermería
The aim of this study was to evaluate the effect of the addition of tomato paste (TP) to sausage mortadella in order to improve the nutritional properties and reduce the lipid oxidation associated with the content of lycopene. First, three different mortadellas without colourant were made with 2,6 and 10% of TP, to optimise technologically the amount of this ingredient. Then, commercial product was compared with 10% of TP mortadella; both products were made with natural colourant. After a proximate analysis only total protein decreased due to the addition of TP. Lycopene content in mortadella and the total antioxidant activity were proportional to the amount of TP added. The presence of TP provided stability during meat grinding, cooking and storage of mortadella by reducing the lipid oxidation. In addition, TP provided yellowness and softness; however, when TP was added together with red colourant, the redness remained constant in the mortadella without effects on the consumer overall acceptance.