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The Nutrition in Early Life and Asthma (NELA) birth cohortstudy: Rationale, design, and methods

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dc.contributor.authorMorales Bartolome, Eva
dc.contributor.authorAlcantara Lopez, Maria V.
dc.contributor.authorCabezas Herrera, Juan
dc.contributor.authorJimenez Guerrero, Pedro
dc.contributor.authorLarque Daza, Elvira
dc.contributor.authorLopez Soler, Concepción
dc.contributor.authorMartinez Gracia, Carmen
dc.contributor.authorMartinez Torres, Antonela
dc.contributor.authorMendiola Olivares, Jaime
dc.contributor.authorNieto Diaz, Anibal
dc.contributor.authorPerez Fernandez, Virginia
dc.contributor.authorPrieto Sanchez, M. Teresa
dc.contributor.authorSalvador Garcia, Carmen
dc.contributor.authorSanchez Solis De Querol, Manuel
dc.contributor.authorTorres Cantero, Alberto
dc.contributor.authorYagüe, Genoveva
dc.contributor.authorZornoza Moreno, Matilde
dc.contributor.authorGarcia-marcos Alvarez, Luis
dc.contributor.authorSantaella-Pascual, Marina
dc.contributor.authorDiego Puente, Teresa de
dc.contributor.authorHernández Caselles, Trinidad
dc.contributor.authorMartín-Orozco Santiago, María Elena
dc.contributor.authorNoguera Velasco, José Antonio
dc.contributor.authorSola Martínez, Rosa Alba
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2023-12-12T23:11:53Z
dc.date.available2023-12-12T23:11:53Z
dc.descriptionThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2021 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd.
dc.descriptionBackground: Primary prevention strategies for asthma are lacking. Its inception probably starts in utero and/or during the early postnatal period as the developmental origins of health and disease (DOHaD) paradigm suggests. Objectives: The main objective of Nutrition in Early Life and Asthma (NELA) cohort study is to unravel whether the following factors contribute causally to the developmental origins of asthma: (1) maternal obesity/adiposity and foetal growth; (2) maternal and child nutrition; (3) outdoor air pollution; (4) endocrine disruptors; and (5) maternal psychological stress. Maternal and offspring biological samples are used to assess changes in offspring microbiome, immune system, epigenome and volatilome as potential mechanisms influencing disease susceptibility. Population: Randomly selected pregnant women from three health areas of Murcia, a south-eastern Mediterranean region of Spain, who fulfilled the inclusion criteria were invited to participate at the time of the follow-up visit for routine foetal anatomy scan at 19–22 weeks of gestation, at the Maternal-Fetal Medicine Unit of the “Virgen de la Arrixaca” University Clinical Hospital over a 36-month period, from March 2015 to April 2018. Design: Prospective, population-based, maternal-child, birth cohort study. Methods: Questionnaires on exposures and outcome variables were administered to mothers at 20–24 gestation week; 32–36 gestation week; and delivery. Children were
dc.formatapplication/pdfes_ES
dc.format.extent15
dc.identifier.citationPaediatric and Perinatal Epidemiology, 2021;00:1–15.
dc.identifier.doihttps://doi.org/10.1111/ppe.12826
dc.identifier.issnPrint: 0269-5022
dc.identifier.issnElectronic: 1365-3016
dc.identifier.urihttp://hdl.handle.net/10201/136573
dc.languageenges_ES
dc.relation.isreferencedbyED_IDENTRADA=1264
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/13653016
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDietes_ES
dc.subjectAllergyes_ES
dc.subjectMother-child cohortes_ES
dc.titleThe Nutrition in Early Life and Asthma (NELA) birth cohortstudy: Rationale, design, and methodses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
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