Publication: Highly selective biocatalytic synthesis of monoacylglycerides in sponge-like ionic liquids
Authors
Gómez, Celia ; Sánchez-Gómez, Gregorio ; García-Verdugo, Eduardo ; Luis, Santiago V. ; Lozano Rodríguez, Pedro ; Nieto Cerón, Susana
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Publisher
RSC
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DOI
10.1039/C6GC01969B
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info:eu-repo/semantics/article
Description
©<2017>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Accepted Manuscript version of a Published Work that appeared in final form in [Green Chemistry]. To access the final edited and published work see[DOI: 10.1039/x0xx00000x]
Abstract
The biocatalytic synthesis of monoacylglycerides (MAGs) was carried out by the direct esterification of fatty acids (i.e. oleic, palmitic, myristic and lauric acids, respectively) with glycerol in different ionic liquids (ILs) based on cations with long alkyl side-chains (i.e. 1-hexadecyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [C16mim][NTf2], 1-dodecyl-3-methylimidazolium tetrafluoroborate [C12mim][BF4]). Although all ILs have been shown as suitable reaction media for Novozym 435-catalyzed esterification of glycerol with free fatty acid, a highly selective selectivity of MAGs was only observed for the [C12mim][BF4] case (i.e up to 99% selectivity and yield for the monolaurin case). Furthermore, as these ILs are temperature switchable ionic liquid/solid phases that behave as sponge-like system, a straightforward protocol for IL-free MSGs recovery, based on iterative centrifugations at controlled temperature, has been developed.
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Citation
Green Chemistry 2017, 19(2), 322-322
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