Publication: Biological significance of dietary polyamines
Authors
Larqué, Elvira ; Sabater Molina, María ; Zamora, Salvador
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.nut.2006.09.006
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info:eu-repo/semantics/article
Description
©2007 Elsevier. This document is the Published, version of a Published Work that appeared in final form in Nutrition. To access the final edited and published work see https://doi.org/10.1016/j.nut.2006.09.006
Abstract
Polyamines are classically known by their names of putrescine, spermine, and spermidine. They are synthesized endogenously from ornithine and are interconvertible. In addition, an exogenous supply of polyamines is provided by dietary intake and by intestinal absorption from the products of bacterial metabolism. Polyamine uptake occurs almost entirely in the gut, and afterward the various forms are metabolized in different tissues under the strict regulation of ornithine decarboxylase, which is the first enzyme involved in their synthesis. Polyamines are eliminated from the organism by means of oxidation reactions, appearing in urine in all their metabolic forms. Polyamines play an important role in regulating cell growth and proliferation, the stabilization of negative charges of DNA, RNA transcription, protein synthesis, apoptosis, and the regulation of the immune response. They are components of breast milk and might be important in neonatal gut maturation, for which reason the possible supplementation of infant formulas with these compounds is under study.
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Citation
Nutrition 23 (2007): 87-95
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