Publication: Effect of diet/atorvastatin on atherosclerotic lesions associated to nonalcoholic fatty liver disease in chickens
Authors
Sánchez-Polo, Maria T. ; García Pérez, Bartolomé ; Martín, Antonia ; Adánez Martínez, María de Gracia ; Ayala de la Peña, Ignacio ; Castells Mora, María Teresa
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-639
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info:eu-repo/semantics/article
Description
Abstract
Comparative histological examination of
both liver and the supra-aortic arteries have not
previously examined the consequences of atherosclerosis
and nonalcoholic fatty liver disease (NAFLD), and their
response to diet and atorvastatin therapy. This study
evaluates the effects of diet alone or in combination with
atorvastatin therapy on the progression/regression of
atherosclerosis and its correlation with NAFLD. This
research was performed on a cohort of chickens on
standard (SD) or hyperlipidemic diets (HD), either with
or without atorvastatin therapy. The development of
atherosclerotic lesions was assessed by histology,
immunohistochemistry and quantitative image analysis
and correlated with liver histology. The lowest levels of
atherosclerotic lesions were found in animals on the HD
for 3 months, followed by 3 months of SD in
combination with oral atorvastatin. There was a strong
association between the histologic findings of
atherosclerosis and those of NAFLD. These studies
show that standard diet and atorvastatin therapy can
positively affect both arterial and hepatic lesions,
influencing the regression of the changes. These results
support the hypothesis that NAFLD and atherosclerosis
may be actually two aspects of a shared disease and
suggest the possibility of regression of both disorders
with dietary and pharmacologic manipulations.
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Citation
Histology and Histopathology, vol.30, nº 12, (2015)
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