Publication:
Effect of diet/atorvastatin on atherosclerotic lesions associated to nonalcoholic fatty liver disease in chickens

Simple item page
dc.contributor.authorSánchez-Polo, Maria T.
dc.contributor.authorGarcía Pérez, Bartolomé
dc.contributor.authorMartín, Antonia
dc.contributor.authorAdánez Martínez, María de Gracia
dc.contributor.authorAyala de la Peña, Ignacio
dc.contributor.authorCastells Mora, María Teresa
dc.date.accessioned2021-02-18T09:29:49Z
dc.date.available2021-02-18T09:29:49Z
dc.date.issued2015
dc.description.abstractComparative histological examination of both liver and the supra-aortic arteries have not previously examined the consequences of atherosclerosis and nonalcoholic fatty liver disease (NAFLD), and their response to diet and atorvastatin therapy. This study evaluates the effects of diet alone or in combination with atorvastatin therapy on the progression/regression of atherosclerosis and its correlation with NAFLD. This research was performed on a cohort of chickens on standard (SD) or hyperlipidemic diets (HD), either with or without atorvastatin therapy. The development of atherosclerotic lesions was assessed by histology, immunohistochemistry and quantitative image analysis and correlated with liver histology. The lowest levels of atherosclerotic lesions were found in animals on the HD for 3 months, followed by 3 months of SD in combination with oral atorvastatin. There was a strong association between the histologic findings of atherosclerosis and those of NAFLD. These studies show that standard diet and atorvastatin therapy can positively affect both arterial and hepatic lesions, influencing the regression of the changes. These results support the hypothesis that NAFLD and atherosclerosis may be actually two aspects of a shared disease and suggest the possibility of regression of both disorders with dietary and pharmacologic manipulations.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol.30, nº 12, (2015)
dc.identifier.doi10.14670/HH-11-639
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/103483
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectAtherosclerosises
dc.subjectChickenes
dc.subjectHyperlipidemiaes
dc.subjectNAFLDes
dc.subjectSupra-aortic trunkes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleEffect of diet/atorvastatin on atherosclerotic lesions associated to nonalcoholic fatty liver disease in chickenses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationd6ad2235-d5ca-4574-85eb-964da3c5c44c
relation.isAuthorOfPublication.latestForDiscoveryd6ad2235-d5ca-4574-85eb-964da3c5c44c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Sanchez-Polo-30-1439-1446-2015.pdf
Size:
1.59 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.30,nº12 (2015)