Publication: Changes in serum biomarkers of oxidative stress after treatment for canine leishmaniosis in sick dogs
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Date
2016-12
Authors
Peres Rubio, Camila ; Martínez-Subiela, Silvia ; Tvarijonaviciute, Asta ; Pardo-Marin, Luis ; Segarra, S. ; Cerón, J.J. ; Hernández Ruiz, Josefa
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.cimid.2016.09.003
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info:eu-repo/semantics/article
Description
© 2016 Elsevier Ltd .
This document is the published version of a published work that appeared in final form in Comparative Immunology, Microbiology and Infectious Diseases .
To access the final edited and published work see:
https://doi.org/10.1016/j.cimid.2016.09.003
Abstract
Canine leishmaniosis (CanL) is a zoonotic disease being endemic in several parts of the world. In this studywe investigated the behavior of a panel of biomarkers of oxidative stress in 12 sick dogs naturally infectedby CanL before and at days 30 and 180 of a successful therapy with a standard treatment. The assays totaloxidant status (TOS), trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma(FRAP), cupric reducing antioxidant capacity (CUPRAC), serum thiol and paraoxonase 1 (PON1) wereincluded in the panel. In addition, correlations between biomarkers of oxidative stress and inflammation(C-reactive protein (CRP) and ferritin) and urinary protein:creatinine ratio (UPC) were calculated. SerumCUPRAC, thiol and PON1 significantly increased after treatment and were negatively correlated with CRP,ferritin and UPC. This study demonstrates that biomarkers of oxidative stress, not previously studied inleishmaniosis such as CUPRAC and thiol, can change after a successful treatment for CanL showing apotential for use in monitoring the treatment of this disease
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Citation
Comparative Immunology, Microbiology and Infectious Diseases, 49, 51-57
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