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Changes in serum biomarkers of oxidative stress after treatment for canine leishmaniosis in sick dogs

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dc.contributor.authorPeres Rubio, Camila
dc.contributor.authorMartínez-Subiela, Silvia
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorPardo-Marin, Luis
dc.contributor.authorSegarra, S.
dc.contributor.authorCerón, J.J.
dc.contributor.authorHernández Ruiz, Josefa
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-02-01T22:17:45Z
dc.date.available2025-02-01T22:17:45Z
dc.date.issued2016-12
dc.description© 2016 Elsevier Ltd . This document is the published version of a published work that appeared in final form in Comparative Immunology, Microbiology and Infectious Diseases . To access the final edited and published work see: https://doi.org/10.1016/j.cimid.2016.09.003
dc.description.abstractCanine leishmaniosis (CanL) is a zoonotic disease being endemic in several parts of the world. In this studywe investigated the behavior of a panel of biomarkers of oxidative stress in 12 sick dogs naturally infectedby CanL before and at days 30 and 180 of a successful therapy with a standard treatment. The assays totaloxidant status (TOS), trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma(FRAP), cupric reducing antioxidant capacity (CUPRAC), serum thiol and paraoxonase 1 (PON1) wereincluded in the panel. In addition, correlations between biomarkers of oxidative stress and inflammation(C-reactive protein (CRP) and ferritin) and urinary protein:creatinine ratio (UPC) were calculated. SerumCUPRAC, thiol and PON1 significantly increased after treatment and were negatively correlated with CRP,ferritin and UPC. This study demonstrates that biomarkers of oxidative stress, not previously studied inleishmaniosis such as CUPRAC and thiol, can change after a successful treatment for CanL showing apotential for use in monitoring the treatment of this disease
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dc.format.extent7
dc.identifier.citationComparative Immunology, Microbiology and Infectious Diseases, 49, 51-57
dc.identifier.doihttps://doi.org/10.1016/j.cimid.2016.09.003
dc.identifier.issnPrint.:0147-9571
dc.identifier.issnElectronic.: 1878-1667
dc.identifier.urihttp://hdl.handle.net/10201/149928
dc.languageenges
dc.publisherElsevier
dc.relation• Seneca Foundation of Murcia Region • Ministerio de Economía y Competitividad • Conselho Nacional de Desenvolvimento Científico e Tecnológicoes
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0147957116300947?via%3Dihub
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAntioxidant
dc.subjectCupric
dc.subjectDogs
dc.subjectFerric
dc.subjectLeishmaniosis
dc.subjectThiolgs
dc.titleChanges in serum biomarkers of oxidative stress after treatment for canine leishmaniosis in sick dogses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication04cc5ea0-ac13-435b-81f3-ea78cdd30554
relation.isAuthorOfPublication.latestForDiscovery04cc5ea0-ac13-435b-81f3-ea78cdd30554
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