Publication: Mast cells or not? - CD117 positive
cells in esophageal leiomyoma
Authors
Ye, Ju Xiang ; Liu, Yan ; Qin, Yun ; Ma, Xiao Long ; Zhong, Hao Hao ; Zhang, Yan ; Shi, Xue Ying
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-30.581
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info:eu-repo/semantics/article
Description
Abstract
The presence of CD117 positive cells in
esophageal leiomyoma may lead to a misdiagnosis of
GIST. We reviewed 46 esophageal tumors which were
smooth muscle tumors or GIST. Based on morphology,
immunohistochemistry and mutation analysis, there were
44 (95.6%) leiomyomas, 1 (2.2%) leiomyosarcoma, and
1 (2.2%) GIST. Variable numbers of CD117 positive
cells were seen in all leiomyomas. Tryptase
immunostaining identified mast cells in 93.2% (41/44)
of leiomyomas, and the number of mast cells per tumor
decreased significantly from tumors of the upper
esophagus to the esophageal-gastric junction (p<0.01).
Immunofluorescence study further confirmed the
presence of two types of CD117 positive spindle cells
which included spindle-shaped mast cells and DOG-1-
positive interstitial cells of Cajal. This is the first study
to systemically review mast cells in esophageal
leiomyomas and tumors which may be included in the
differential diagnosis. We demonstrate that both spindled
mast cells and hyperplastic interstitial cells of Cajal are
present within esophageal leiomyomas. The
immunoreactivity of these cells with CD117 may
suggest a diagnosis of GIST, but the presence of mast
cells itself supports a diagnosis of esophageal
leiomyoma.
Citation
Histology and Histopathology, Vol. 30, n.º 5 (2015)
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