Browsing by Subject "Leiomyoma"

Now showing 1 - 2 of 2
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    Mast cells or not? - CD117 positive cells in esophageal leiomyoma
    (F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología, 2015) Ye, Ju Xiang; Liu, Yan; Qin, Yun; Ma, Xiao Long; Zhong, Hao Hao; Zhang, Yan; Shi, Xue Ying
    The presence of CD117 positive cells in esophageal leiomyoma may lead to a misdiagnosis of GIST. We reviewed 46 esophageal tumors which were smooth muscle tumors or GIST. Based on morphology, immunohistochemistry and mutation analysis, there were 44 (95.6%) leiomyomas, 1 (2.2%) leiomyosarcoma, and 1 (2.2%) GIST. Variable numbers of CD117 positive cells were seen in all leiomyomas. Tryptase immunostaining identified mast cells in 93.2% (41/44) of leiomyomas, and the number of mast cells per tumor decreased significantly from tumors of the upper esophagus to the esophageal-gastric junction (p<0.01). Immunofluorescence study further confirmed the presence of two types of CD117 positive spindle cells which included spindle-shaped mast cells and DOG-1- positive interstitial cells of Cajal. This is the first study to systemically review mast cells in esophageal leiomyomas and tumors which may be included in the differential diagnosis. We demonstrate that both spindled mast cells and hyperplastic interstitial cells of Cajal are present within esophageal leiomyomas. The immunoreactivity of these cells with CD117 may suggest a diagnosis of GIST, but the presence of mast cells itself supports a diagnosis of esophageal leiomyoma.
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    Simultaneous uterine leiomyoma and endometrial hiperplasia in a white-nosed monkey (cercopithecus nictitans). First case report
    (Murcia, Universidad de Murcia, Servicio de Publicaciones, 2010) Ibáñez, Carla; Corpa, Juan M.; Martínez Cáceres, Carlos Manuel; Facultad de Veterinaria
    This paper describes histopathological and immunocytochemical features of a combined uterine leyomioma and a non atypical complex endometrial hyperplasia in a white-nosed monkey (Cercopithecus nictitans). Immunocytochemically, uterine leiomyoma was a-actin positive, and negative for desmin. By the other hand, endometrial hyperplasia showed strong immunoreaction against ciclin D1, cyclooxygenase-2 (COX-2), oestrogen receptor, isoform A of progesterone receptor and slight p53 immunoreaction. This is the first immunocytochemical description of an endometrial hyperplasia in a white-nosed monkey. This lesional spectrum, similar to those described in human pathology, suggests similar pathogenic mechanisms