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Mast cells or not? - CD117 positive cells in esophageal leiomyoma

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dc.contributor.authorYe, Ju Xiang
dc.contributor.authorLiu, Yan
dc.contributor.authorQin, Yun
dc.contributor.authorMa, Xiao Long
dc.contributor.authorZhong, Hao Hao
dc.contributor.authorZhang, Yan
dc.contributor.authorShi, Xue Ying
dc.date.accessioned2020-04-21T11:35:01Z
dc.date.available2020-04-21T11:35:01Z
dc.date.issued2015
dc.description.abstractThe presence of CD117 positive cells in esophageal leiomyoma may lead to a misdiagnosis of GIST. We reviewed 46 esophageal tumors which were smooth muscle tumors or GIST. Based on morphology, immunohistochemistry and mutation analysis, there were 44 (95.6%) leiomyomas, 1 (2.2%) leiomyosarcoma, and 1 (2.2%) GIST. Variable numbers of CD117 positive cells were seen in all leiomyomas. Tryptase immunostaining identified mast cells in 93.2% (41/44) of leiomyomas, and the number of mast cells per tumor decreased significantly from tumors of the upper esophagus to the esophageal-gastric junction (p<0.01). Immunofluorescence study further confirmed the presence of two types of CD117 positive spindle cells which included spindle-shaped mast cells and DOG-1- positive interstitial cells of Cajal. This is the first study to systemically review mast cells in esophageal leiomyomas and tumors which may be included in the differential diagnosis. We demonstrate that both spindled mast cells and hyperplastic interstitial cells of Cajal are present within esophageal leiomyomas. The immunoreactivity of these cells with CD117 may suggest a diagnosis of GIST, but the presence of mast cells itself supports a diagnosis of esophageal leiomyoma.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol. 30, n.º 5 (2015)
dc.identifier.doihttps://doi.org/10.14670/HH-30.581
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/90169
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEsophaguses
dc.subjectGISTes
dc.subjectLeiomyomaes
dc.subjectMast celles
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleMast cells or not? - CD117 positive cells in esophageal leiomyomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº5 (2015)