Publication:
Alendronate effect in esophagus, stomach and liver: An animal based pathological study

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Papamitsou-35-417-422-2020.pdf(13.45 MB)
Date
2020
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Authors
Papamitsou, Theodora ; Sotiriou, Sotiris ; Papakoulas, Apostolos ; Toskas, Alexandros ; Kamperis, Dimitrios ; Karachrysafi, Sofia ; Dietrich, Eva-Maria ; Lialiaris, Stergios ; Sioga, Antonia
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-161
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info:eu-repo/semantics/article
Description
Abstract
Bisphosphonates are commonly used in clinical practice. Their effectiveness is indisputable, however their adverse effects, especially in the GI tract, are still controversial. In our report, we demonstrate pathological findings of the effect of systematic alendronate administration in esophagus, stomach and the liver of an in vivo animal model of 15 Wistar rats. Light microscopy with immunohistochemistry and electron microscopy were used. Microscopic findings of inflammation of the stomach and mild hepatic dysfunction were observed. Conclusively, alendronate can potentially affect gastric mucosa and liver function on this animal experimental model
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Alendronate , Esophagus , Stomach , Liver , Immunohistochemistry , Electron microscopy
Citation
Histology and Histopathology Vol. 35, nº4 (2020)
URI
http://hdl.handle.net/10201/125585
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Histology and histopathology Vol.35, nº4 (2020)
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