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Alendronate effect in esophagus, stomach and liver: An animal based pathological study

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dc.contributor.authorPapamitsou, Theodora
dc.contributor.authorSotiriou, Sotiris
dc.contributor.authorPapakoulas, Apostolos
dc.contributor.authorToskas, Alexandros
dc.contributor.authorKamperis, Dimitrios
dc.contributor.authorKarachrysafi, Sofia
dc.contributor.authorDietrich, Eva-Maria
dc.contributor.authorLialiaris, Stergios
dc.contributor.authorSioga, Antonia
dc.date.accessioned2022-11-15T10:42:47Z
dc.date.available2022-11-15T10:42:47Z
dc.date.issued2020
dc.description.abstractBisphosphonates are commonly used in clinical practice. Their effectiveness is indisputable, however their adverse effects, especially in the GI tract, are still controversial. In our report, we demonstrate pathological findings of the effect of systematic alendronate administration in esophagus, stomach and the liver of an in vivo animal model of 15 Wistar rats. Light microscopy with immunohistochemistry and electron microscopy were used. Microscopic findings of inflammation of the stomach and mild hepatic dysfunction were observed. Conclusively, alendronate can potentially affect gastric mucosa and liver function on this animal experimental modeles
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dc.format.extent6es
dc.identifier.citationHistology and Histopathology Vol. 35, nº4 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-161
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/125585
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlendronatees
dc.subjectEsophaguses
dc.subjectStomaches
dc.subjectLiveres
dc.subjectImmunohistochemistryes
dc.subjectElectron microscopyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAlendronate effect in esophagus, stomach and liver: An animal based pathological studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº4 (2020)