Publication: Idiopathic pulmonary fibrosis: Are any of the morphological-molecular markers useful in clinical management?
Authors
Lunardi, Francesca ; Balestro, Elisabetta ; Nannini, Nazarena ; Vuljan, Stefania Edith ; Rea, Federico ; Calabrese, Fiorella
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-851
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info:eu-repo/semantics/article
Description
Abstract
Idiopathic pulmonary fibrosis (IPF), the most
common form of chronic interstitial lung disease, is a
severe progressive fibrotic disorder of unknown
aetiology. The disease has a heterogeneous clinical
course, with frequent poor prognosis, similar to
malignant disease. Correctly diagnosing IPF has become
particularly important in view of the availability of more
precise therapeutic indications, thus avoiding steroid
treatment and allowing new approaches with novel
drugs.
To date we have limited information about
biomarkers predictive of progressive disease and
associated complications. Efforts should be made in the
future to more appropriately study lung tissue and then
to extrapolate the most clinically fitting biomarkers.
This approach is already used in routine
management of many cancers and provides a potential
road map for more appropriate clinical care of IPF.
This review will mainly focus on histology and
etiopathogenesis highlighting some morphological and
molecular features that may influence the overall
management of IPF.
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Citation
Histology and Histopathology, Vol.32, nÂş7, (2017)
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