Browsing by Subject "Markers"

Now showing 1 - 2 of 2
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    Open Access
    Advances in the knowledge of breast cancer stem cells. A review
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Schwarz-Cruz y Celis, Angela; Espinosa, Magali; Maldonado, Vilma; Melendez-Zajgla, Jorge
    Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis and the development of drug resistance. These findings make the need to find the distinguishing blend of markers that can recognize only BCSCs of the utmost importance in order to be able to design new targeted therapies. This review will summarize BCSCs’ main features as well as the cell surface markers that are currently used to identify them.
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    Publication
    Open Access
    Idiopathic pulmonary fibrosis: Are any of the morphological-molecular markers useful in clinical management?
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2017) Lunardi, Francesca; Balestro, Elisabetta; Nannini, Nazarena; Vuljan, Stefania Edith; Rea, Federico; Calabrese, Fiorella
    Idiopathic pulmonary fibrosis (IPF), the most common form of chronic interstitial lung disease, is a severe progressive fibrotic disorder of unknown aetiology. The disease has a heterogeneous clinical course, with frequent poor prognosis, similar to malignant disease. Correctly diagnosing IPF has become particularly important in view of the availability of more precise therapeutic indications, thus avoiding steroid treatment and allowing new approaches with novel drugs. To date we have limited information about biomarkers predictive of progressive disease and associated complications. Efforts should be made in the future to more appropriately study lung tissue and then to extrapolate the most clinically fitting biomarkers. This approach is already used in routine management of many cancers and provides a potential road map for more appropriate clinical care of IPF. This review will mainly focus on histology and etiopathogenesis highlighting some morphological and molecular features that may influence the overall management of IPF.