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Idiopathic pulmonary fibrosis: Are any of the morphological-molecular markers useful in clinical management?

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dc.contributor.authorLunardi, Francesca
dc.contributor.authorBalestro, Elisabetta
dc.contributor.authorNannini, Nazarena
dc.contributor.authorVuljan, Stefania Edith
dc.contributor.authorRea, Federico
dc.contributor.authorCalabrese, Fiorella
dc.date.accessioned2022-02-24T07:51:49Z
dc.date.available2022-02-24T07:51:49Z
dc.date.issued2017
dc.description.abstractIdiopathic pulmonary fibrosis (IPF), the most common form of chronic interstitial lung disease, is a severe progressive fibrotic disorder of unknown aetiology. The disease has a heterogeneous clinical course, with frequent poor prognosis, similar to malignant disease. Correctly diagnosing IPF has become particularly important in view of the availability of more precise therapeutic indications, thus avoiding steroid treatment and allowing new approaches with novel drugs. To date we have limited information about biomarkers predictive of progressive disease and associated complications. Efforts should be made in the future to more appropriately study lung tissue and then to extrapolate the most clinically fitting biomarkers. This approach is already used in routine management of many cancers and provides a potential road map for more appropriate clinical care of IPF. This review will mainly focus on histology and etiopathogenesis highlighting some morphological and molecular features that may influence the overall management of IPF.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology, Vol.32, nÂş7, (2017)
dc.identifier.doiDOI: 10.14670/HH-11-851
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/117364
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectIPFes
dc.subjectMorphologyes
dc.subjectMarkerses
dc.subjectManagementes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleIdiopathic pulmonary fibrosis: Are any of the morphological-molecular markers useful in clinical management?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nÂş7 (2017)