Publication: a-synuclein: between synaptic function and dysfunction
Date
2003
Authors
Di Rosa, G. ; Puzzo, D. ; Sant'Angelo, A. ; Trinchese, F. ; Arancio, O.
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Alpha-synuclein belongs to a family of vertebrate proteins, encoded by three different genes: a, ß, and g. The protein has become of interest to the neuroscience community in the last few years after the discovery that a mutation in the a-synuclein gene is associated with familial autosomal-dominant early-onset forms of Parkinson Disease. However, it is not yet clear how the protein is involved in the disease. Several studies have suggested that a-synuclein plays a role in neurotransmitter release and synaptic plasticity. This hypothesis might help elucidate how a-synuclein malfunctioning contributes to the development of a series of disorders known as synucleinopathies.
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