Browsing by Subject "Neurotransmission"

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    a-synuclein: between synaptic function and dysfunction
    (2003) Di Rosa, G.; Puzzo, D.; Sant'Angelo, A.; Trinchese, F.; Arancio, O.
    Alpha-synuclein belongs to a family of vertebrate proteins, encoded by three different genes: a, ß, and g. The protein has become of interest to the neuroscience community in the last few years after the discovery that a mutation in the a-synuclein gene is associated with familial autosomal-dominant early-onset forms of Parkinson Disease. However, it is not yet clear how the protein is involved in the disease. Several studies have suggested that a-synuclein plays a role in neurotransmitter release and synaptic plasticity. This hypothesis might help elucidate how a-synuclein malfunctioning contributes to the development of a series of disorders known as synucleinopathies.
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    Immunocytochemical localization of metabotropic (mGluR2/3 and mGluR4a) and ionotropic (GluR2/3) glutamate receptors in adrenal medullary ganglion cells
    (Murcia : F. Hernández, 2006) Sarría, R.; Díez, J.; Losada, J.; Doñate-Oliver, F.; Kuhn, R.; Grandes, P.
    The localization of metabotropic glutamate receptors of groups II (mGluR2/3) and III (mGluR4a) and the subunits 2 and 3 of alfa-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) ionotropic glutamate receptors (GluR2/3) was investigated with immunocytochemical methods in the rat adrenal gland. MGluR2/3, mGluR4a and GluR2/3 immunoreactivities were observed in large-sized, centrally located type I adrenal medullary ganglion neurons. Furthermore, the small-sized type II adrenal ganglion neurons identified by their immunoreactivity to brain nitric oxide synthase (bNOS), also expressed mGluR2/3, mGluR4a and GluR2/3. These cells were disposed in the peripheral portion of the adrenal medulla. None of the type I neurons were positively labeled for bNOS. These morphological observations suggest that activation of glutamate receptors in ganglion neurons may be instrumental in the control of adrenal endocrine systems as well as blood regulation.