Browsing by Subject "Synuclein"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
PublicationMetadata onlya-synuclein: between synaptic function and dysfunction(2003) Di Rosa, G.; Puzzo, D.; Sant'Angelo, A.; Trinchese, F.; Arancio, O.Alpha-synuclein belongs to a family of vertebrate proteins, encoded by three different genes: a, ß, and g. The protein has become of interest to the neuroscience community in the last few years after the discovery that a mutation in the a-synuclein gene is associated with familial autosomal-dominant early-onset forms of Parkinson Disease. However, it is not yet clear how the protein is involved in the disease. Several studies have suggested that a-synuclein plays a role in neurotransmitter release and synaptic plasticity. This hypothesis might help elucidate how a-synuclein malfunctioning contributes to the development of a series of disorders known as synucleinopathies.