Publication: New advances on critical implications of tumorand
metastasis-initiating cells in cancer progression,
treatment resistance and disease recurrence
Authors
Mimeault, M. ; Batra, Surinder K.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Accumulating lines of experimental evidence
have revealed that the malignant transformation of
multipotent tissue-resident adult stem/progenitor cells
into cancer stem/progenitor cells endowed with a high
self-renewal capacity and aberrant multilineage
differentiation potential may be at origin of the most
types of human aggressive and recurrent cancers. Based
on new cancer stem/progenitor cell concepts of
carcinogenesis, it is suggested that a small subpopulation
of highly tumorigenic and migrating cancer
stem/progenitor cells, also designated as cancer- and
metastasis-initiating cells, can provide critical roles for
primary tumor growth, metastases at distant tissues and
organs, treatment resistance and disease relapse.
Particularly, cancer initiation and progression to locally
invasive and metastatic stages is often associated with a
persistent activation of distinct developmental signaling
pathways in these immature cells during epithelialmesenchymal
transition program. The signaling cascades
that are often deregulated in cancer stem/progenitor cells
include hedgehog, epidermal growth factor receptor
(EGFR), Wnt/ß-catenin, NOTCH, polycomb gene
product BMI-1 and/or stromal cell-derived factor-1
(SDF-1)/CXC chemokine receptor 4 (CXCR4).
Importantly, the results from recent investigations have
also indicated that different cancer subtypes may harbor
distinct subsets and/or number of cancer-initiating cells
during cancer progression as well as before or after therapy initiation and disease recurrence. Therefore, the
identification of the molecular transforming events that
frequently occur in cancer- and metastasis-initiating cells
versus their differentiated progenies is of immense
interest to develop new targeting approach for improving
current therapies against aggressive, metastatic,
recurrent and lethal cancers.
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