New advances on critical implications of tumorand
metastasis-initiating cells in cancer progression,
treatment resistance and disease recurrence

Mimeault, M.; Batra, Surinder K.

Publication:
New advances on critical implications of tumorand metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence

dc.contributor.author	Mimeault, M.
dc.contributor.author	Batra, Surinder K.
dc.date.accessioned	2015-10-13T14:48:08Z
dc.date.available	2015-10-13T14:48:08Z
dc.date.issued	2010
dc.description.abstract	Accumulating lines of experimental evidence have revealed that the malignant transformation of multipotent tissue-resident adult stem/progenitor cells into cancer stem/progenitor cells endowed with a high self-renewal capacity and aberrant multilineage differentiation potential may be at origin of the most types of human aggressive and recurrent cancers. Based on new cancer stem/progenitor cell concepts of carcinogenesis, it is suggested that a small subpopulation of highly tumorigenic and migrating cancer stem/progenitor cells, also designated as cancer- and metastasis-initiating cells, can provide critical roles for primary tumor growth, metastases at distant tissues and organs, treatment resistance and disease relapse. Particularly, cancer initiation and progression to locally invasive and metastatic stages is often associated with a persistent activation of distinct developmental signaling pathways in these immature cells during epithelialmesenchymal transition program. The signaling cascades that are often deregulated in cancer stem/progenitor cells include hedgehog, epidermal growth factor receptor (EGFR), Wnt/ß-catenin, NOTCH, polycomb gene product BMI-1 and/or stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4). Importantly, the results from recent investigations have also indicated that different cancer subtypes may harbor distinct subsets and/or number of cancer-initiating cells during cancer progression as well as before or after therapy initiation and disease recurrence. Therefore, the identification of the molecular transforming events that frequently occur in cancer- and metastasis-initiating cells versus their differentiated progenies is of immense interest to develop new targeting approach for improving current therapies against aggressive, metastatic, recurrent and lethal cancers.	es
dc.format	application/pdf	es
dc.format.extent	17	es
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/46604
dc.language	eng	es
dc.publisher	Murcia: F. Hernández	es
dc.relation.ispartof	Histology and histopathology, Vol. 25, nº 8 (2010)	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Solid tumors	es
dc.subject	Metastases	es
dc.subject	Cancer therapy	es
dc.subject.other	577 - Bioquímica. Biología molecular. Biofísica	es
dc.title	New advances on critical implications of tumorand metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es