Publication: Self-reported DHA supplementation during pregnancy and its association with obesity or gestational diabetes in relation to DHA concentration in cord and maternal plasma: results from NELA, a prospective mother-offspring cohort.
Authors
Gázquez, Antonio ; Giménez-Bañón, María J. ; Prieto-Sánchez, Maria T. ; Martínez-Graciá, Carmen ; Suárez, Clara ; Morales, Eva ; García-Marcos, Luis ; Larqué, Elvira ; Galdo-Castiñeira, Lina ; Ballesteros-Meseguer, Carmen ; Vioque, Jesús ; Santaella-Pascual, Marina ; Avilés Plaza, Francisco Valeriano ; Martínez Villanueva, Miriam ; Noguera Velasco, José Antonio
item.page.secondaryauthor
item.page.director
Publisher
publication.page.editor
publication.page.department
DOI
https://doi.org/10.3390/nu13030843
item.page.type
info:eu-repo/semantics/article
Description
©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the Published, version of a Published Work that appeared in final form in Nutrients. To access the final edited and published work see https://doi.org/10.3390/nu13030843
Abstract
Maternal supplementation of docosahexaenoic acid (DHA) during pregnancy has been recommended due to its role in infant development, but its effect on materno-fetal DHA status is not well established. We evaluated the associations between DHA supplementation in pregnant women with obesity or gestational diabetes mellitus (GDM) and maternal and neonatal DHA status. Serum fatty acids (FA) were analyzed in 641 pregnant women (24 weeks of gestation) and in 345 venous and 166 arterial cord blood samples of participants of the NELA cohort. Obese women (n = 47) presented lower DHA in serum than those lean (n = 397) or overweight (n = 116) before pregnancy. Linoleic acid in arterial cord was elevated in obese women, which indicates lower fetal retention. Maternal DHA supplementation (200 mg/d) during pregnancy was associated with enhanced maternal and fetal DHA levels regardless of pre-pregnancy body mass index (BMI), although higher arterial DHA in overweight women indicated an attenuated response. Maternal DHA supplementation was not associated with cord venous DHA in neonates of mothers with GDM. The cord arteriovenous difference was similar for DHA between GDM and controls. In conclusion, maternal DHA supplementation during pregnancy enhanced fetal DHA status regardless of the pre-pregnancy BMI while GDM may reduce the effect of DHA supplementation in newborns.
publication.page.subject
Citation
Nutrients. 2021 Mar 4 13(3):843
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/