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Self-reported DHA supplementation during pregnancy and its association with obesity or gestational diabetes in relation to DHA concentration in cord and maternal plasma: results from NELA, a prospective mother-offspring cohort.

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dc.contributor.authorGázquez, Antonio
dc.contributor.authorGiménez-Bañón, María J.
dc.contributor.authorPrieto-Sánchez, Maria T.
dc.contributor.authorMartínez-Graciá, Carmen
dc.contributor.authorSuárez, Clara
dc.contributor.authorMorales, Eva
dc.contributor.authorGarcía-Marcos, Luis
dc.contributor.authorLarqué, Elvira
dc.contributor.authorGaldo-Castiñeira, Lina
dc.contributor.authorBallesteros-Meseguer, Carmen
dc.contributor.authorVioque, Jesús
dc.contributor.authorSantaella-Pascual, Marina
dc.contributor.authorAvilés Plaza, Francisco Valeriano
dc.contributor.authorMartínez Villanueva, Miriam
dc.contributor.authorNoguera Velasco, José Antonio
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.contributor.departmentFisiología
dc.contributor.departmentTecnología de Alimentos, Nutrición y Bromatología
dc.date.accessioned2024-02-11T17:46:45Z
dc.date.available2024-02-11T17:46:45Z
dc.date.issued2021-03
dc.description©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published, version of a Published Work that appeared in final form in Nutrients. To access the final edited and published work see https://doi.org/10.3390/nu13030843es
dc.description.abstractMaternal supplementation of docosahexaenoic acid (DHA) during pregnancy has been recommended due to its role in infant development, but its effect on materno-fetal DHA status is not well established. We evaluated the associations between DHA supplementation in pregnant women with obesity or gestational diabetes mellitus (GDM) and maternal and neonatal DHA status. Serum fatty acids (FA) were analyzed in 641 pregnant women (24 weeks of gestation) and in 345 venous and 166 arterial cord blood samples of participants of the NELA cohort. Obese women (n = 47) presented lower DHA in serum than those lean (n = 397) or overweight (n = 116) before pregnancy. Linoleic acid in arterial cord was elevated in obese women, which indicates lower fetal retention. Maternal DHA supplementation (200 mg/d) during pregnancy was associated with enhanced maternal and fetal DHA levels regardless of pre-pregnancy body mass index (BMI), although higher arterial DHA in overweight women indicated an attenuated response. Maternal DHA supplementation was not associated with cord venous DHA in neonates of mothers with GDM. The cord arteriovenous difference was similar for DHA between GDM and controls. In conclusion, maternal DHA supplementation during pregnancy enhanced fetal DHA status regardless of the pre-pregnancy BMI while GDM may reduce the effect of DHA supplementation in newborns.es
dc.formatapplication/pdfes
dc.format.extent18es
dc.identifier.citationNutrients. 2021 Mar 4 13(3):843
dc.identifier.doihttps://doi.org/10.3390/nu13030843
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10201/139245
dc.languageenges
dc.relationhis study was supported by grants from Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER (grant numbers CP14/00046, PIE15/00051, PI16/00422, PI19/00863 and ARADyAL network RD160006). Maternal and Child Health and Development Research Network (RED SAMID III, RD 16/0022/0009) and the Research Excellence Group CHRONOHEALTH (Séneca Foundation, 19899/GERM/15, Murcia).es
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000695/es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleSelf-reported DHA supplementation during pregnancy and its association with obesity or gestational diabetes in relation to DHA concentration in cord and maternal plasma: results from NELA, a prospective mother-offspring cohort.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication2d5dac0f-c6c6-485b-97bf-c679f4940e3d
relation.isAuthorOfPublication78abb44c-db12-4773-ae35-2608e3f81343
relation.isAuthorOfPublication9c9ff94c-e612-43b2-b9d7-bf971fc48804
relation.isAuthorOfPublicationf3810358-f28e-4db9-88fb-457b1c3f4a1f
relation.isAuthorOfPublication.latestForDiscovery2d5dac0f-c6c6-485b-97bf-c679f4940e3d
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