Publication: Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and K-carrageenan.
Authors
Rosas Durazo, A. ; Lizardi, J. ; Higuera Ciapara, I. ; Argüelles Monal, W. ; Goycoolea Valencia, Francisco Martín
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Facultades de la UMU::Facultad de Biología
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.colsurfb.2011.03.020
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info:eu-repo/semantics/article
Description
Abstract
The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of κ-carrageenan (at molar charge ratios of Z ≤ 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size ∼250–330 nm and zeta potential (ζ) ranging from ∼+80 to +7 mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.
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Citation
Rosas-Durazo A., Lizardi J., Higuera-Ciapara I., Argüelles-Monal W., *Goycoolea F.M. (2011). Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and K-carrageenan. Colloids Surf B Biointerfaces. 86, 242-246.
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