Publication:
Biological response to porcine xenograft implants: an experimental study in rabbits

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Date
2012-04
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Authors
Calvo Guirado, José Luis ; Gómez Moreno, Gerardo ; Guardia, Javier ; Ortiz Ruiz, Antonio José ; Piatelli, Adriano ; Barone, Antonio ; Martínez González, José María ; Meseguer Olmo, Luis ; López Marí, Laura ; Barona Dorado, Cristina
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Publisher
Lippincott Williams & Wilkins
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Dermatología, Estomatología, Radiología y Medicina Física
DOI
https://doi.org/10.1097/ID.0b013e3182425991
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info:eu-repo/semantics/article
Description
© 2012 by Lippincott Williams & Wilkins. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published version of a Published Work that appeared in final form in Implant Dentistry. To access the final edited and published work see https://doi.org/10.1097/ID.0b013e3182425991
Abstract
Purpose: The aim of this study was to evaluate the effect of a new porcine biomaterial and collagen paste in 20 New Zealand rabbits. Materials and Methods: Forty implants using a porcine xenograft made up of 80% corticocancellous collagenated bone particles of ≤300 μm in size were placed in the proximal metaphyseal area of both tibiae. Four periods of time were formed: 1h, 5, 8, and 15 months. After implantation, an anteroposterior and lateral radiological study was carried out. Samples were sectioned at 5 μm and stained using hematoxylin-eosin, Masson's trichromic, and Gordon-Switt reticulin stains. Results: These results confirmed the biocompatibility of this porcine biomaterial-collagen paste; only a few, occasional macrophages and scattered lymphocytes were observed. No fibrosis was observed between the implants and the bone. Moreover, the material was osteoconductive acting as a “scaffold” for bone cells, and there was a progressive increase in bone growth in and around the implants. Conclusion: This new porcine biomaterial-collagen paste seemed to be biocompatible, bioresorbable, and osteoconductive.
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Biomaterial , Porcine bone , Xenografts , Hydroxyapatite
Citation
Implant Dentistry, 2012, Vol. 21 (2), pp. 112-117
URI
http://hdl.handle.net/10201/142619
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