Histology and histopathology Vol.35, nº5 (2020)

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Browsing Histology and histopathology Vol.35, nº5 (2020) by Author "Antonelli, Alessandro"

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    Role of androgen receptor expression in non-muscle-invasive bladder cancer: a systematic review and meta-analysis
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2020) Sanguedolce, Francesca; Cormio, Luigi; Carrieri, Giuseppe; Calò, Beppe; Russo, Davide; Menin, Andrea; Pastore, Antonio Luigi; Greco, Francesco; Bozzini, Giorgio; Galfano, Antonio; Pini, Giovannalberto; Porreca, Angelo; Mugavero, Filippo; Falsaperla, Mario; Ceruti, Carlo; Cindolo, Luca; Antonelli, Alessandro; Minervini, Andrea
    In order to evaluate the potential prognostic/predictive role of androgen receptor (AR) expression in non-muscle-invasive bladder cancer (NMIBC), and whether it may represent a therapeutic target, we conducted a systematic search of the literature using ‘androgen receptor or AR’, ‘testosterone’, ‘bladder cancer’ and ‘non-muscle invasive bladder cancer or NMIBC’ as keywords. Eleven studies met the inclusion/exclusion criteria. No significant association was found between AR status and patients’ gender (p=0.232), tumor size (p=0.975), tumor stage (p=0.237), tumor grade (p=0.444), tumor multicentricity (p=0.397), concomitant CIS (p=0.316) and progression of disease (p=0.397). On the other hand, relative lack of AR expression was significantly correlated to recurrent disease (p=0.001). Evidence for a direct correlation between AR expression and recurrence-free survival of patients with NMIBC indicate ARs as potential markers of BC behavior; moreover, the finding of a role of androgen blockade therapy in improving survival highlights the potential clinical application of this pathway, which deserves to be further explored.