Publication:
Role of androgen receptor expression in non-muscle-invasive bladder cancer: a systematic review and meta-analysis

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Sanguedolce-35-423-432-2020.pdf(2.22 MB)
Date
2020
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Authors
Sanguedolce, Francesca ; Cormio, Luigi ; Carrieri, Giuseppe ; Calò, Beppe ; Russo, Davide ; Menin, Andrea ; Pastore, Antonio Luigi ; Greco, Francesco ; Bozzini, Giorgio ; Galfano, Antonio ; Pini, Giovannalberto ; Porreca, Angelo ; Mugavero, Filippo ; Falsaperla, Mario ; Ceruti, Carlo ; Cindolo, Luca ; Antonelli, Alessandro ; Minervini, Andrea
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-189
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info:eu-repo/semantics/article
Description
Abstract
In order to evaluate the potential prognostic/predictive role of androgen receptor (AR) expression in non-muscle-invasive bladder cancer (NMIBC), and whether it may represent a therapeutic target, we conducted a systematic search of the literature using ‘androgen receptor or AR’, ‘testosterone’, ‘bladder cancer’ and ‘non-muscle invasive bladder cancer or NMIBC’ as keywords. Eleven studies met the inclusion/exclusion criteria. No significant association was found between AR status and patients’ gender (p=0.232), tumor size (p=0.975), tumor stage (p=0.237), tumor grade (p=0.444), tumor multicentricity (p=0.397), concomitant CIS (p=0.316) and progression of disease (p=0.397). On the other hand, relative lack of AR expression was significantly correlated to recurrent disease (p=0.001). Evidence for a direct correlation between AR expression and recurrence-free survival of patients with NMIBC indicate ARs as potential markers of BC behavior; moreover, the finding of a role of androgen blockade therapy in improving survival highlights the potential clinical application of this pathway, which deserves to be further explored.
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Androgen receptor , Non-muscle-invasive bladder cancer , Immunohistochemistry , Prognosis , Biomarkers
Citation
Histology and Histopathology Vol. 35, nº5 (2020)
URI
http://hdl.handle.net/10201/125684
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Histology and histopathology Vol.35, nº5 (2020)
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