Publication: Vacuolar-type proton pump ATPases: Acidification and pathological relationships
Authors
Sun-Wada, Ge-Hong ; Wada, Yoh
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Vacuolar H + -translocating ATPase (V-
ATPase) is a universal proton pump, and its activity is
required for a variety of cell biological processes, such
as membrane trafficking, receptor-mediated endocytosis,
lysosomal degradation of macromolecules, osteoclastic
bone resorption, and the maintenance of acid-base
homeostasis by renal intercalated cells. V-ATPase is
targeted to various membranes and has different
compositions depending on its cellular location. Here,
we focus on recent knowledge concerning the targeting
mechanism of V-ATPase, a process associated with a
wide spectrum of diseases. We also discuss the functions
of this enzyme in macrophages and cancer
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Citation
Histology and histopathology, Vol. 28, n.º 7 (2013)
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