Browsing by Subject "V-ATPase"

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    Vacuolar-type proton pump ATPases: Acidification and pathological relationships
    (F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología, 2013) Sun-Wada, Ge-Hong; Wada, Yoh
    Vacuolar H + -translocating ATPase (V- ATPase) is a universal proton pump, and its activity is required for a variety of cell biological processes, such as membrane trafficking, receptor-mediated endocytosis, lysosomal degradation of macromolecules, osteoclastic bone resorption, and the maintenance of acid-base homeostasis by renal intercalated cells. V-ATPase is targeted to various membranes and has different compositions depending on its cellular location. Here, we focus on recent knowledge concerning the targeting mechanism of V-ATPase, a process associated with a wide spectrum of diseases. We also discuss the functions of this enzyme in macrophages and cancer