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Palatal shelf reorientation in hamster embryos following treatment with 5-fluorouracil

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dc.contributor.authorShah, Ravindra M.es
dc.contributor.authorChen, Yung Pinges
dc.contributor.authorBurdett, David N.
dc.date.accessioned2011-02-22T10:29:12Z
dc.date.available2011-02-22T10:29:12Z
dc.date.issued1989
dc.description.abstractA study was undertaken to examine the issue of whether achieving a critical mass of cells andor palatal shelf volume during vertical development of shelf is essential for reorientation to occur. In control and 5- fluorouracil (5FU)-treated hamster embryos' palatal shelves, at different times during gestation, the numbers of both epithelial and mesenchymal cells were counted and cross-sectional area was measured. DNA synthesis was measured by 3H-thymidine incorporation and was used as an index of growth by cell proliferation. The control data indicated that, unlike development during initial 24 hours, the later period of vertical palatal development was characterized by a steady level of mesenchymal and epithelial cell numbers and palatal shelf area. Following 5FU treatment all the measurements were reduced, and until they reached the equivalent of control values, the palatal shelves did not reorient. The density of mesenchymal cells in the developing palate did not seem to affect cell number. On the basis of the analysis of results of the present study, along with those reported in the literature, it is suggested that, in hamsters, acquisition and maintenance of both a specified number of mesenchymal cells and shelf area, at least 24 hours prior to reorientation, may be critical for ensuing mesenchymal differentiation to enforce palatal shelf reorientation on schedule. 5FU affected these features to delay reorientation of the palatal shelf.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18679
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subject5-fluorouracilen_EN
dc.subjectDNA synthesisen_EN
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titlePalatal shelf reorientation in hamster embryos following treatment with 5-fluorouracilen_EN
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 4, nº 4 (1989)