Publication: Serum ferritin in obese dogs: changes and comparison with other analytes
Authors
Franco Martínez, Lorena ; Pardo Marín, Luis ; Sánchez Mateos, Laura ; Muñoz Prieto, Alberto ; García Martínez, Juan Diego ; Cerón, José J. ; Martínez Subiela, Silvia ; Rubio, Camila P. ; Tvarijonaviciute, Asta
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Publisher
MDPI
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DOI
https://doi.org/10.3390/vetsci10070457
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info:eu-repo/semantics/article
Description
© 2023 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published Manuscript version of a Published Work that appeared in final form in Veterinary Sciences. To access the final edited and published work see https://doi.org/10.3390/vetsci10070457
Abstract
Canine obesity is the most common nutritional disorder and is associated with decreased quality of life and longevity as well as comorbidities including cardiorespiratory, endocrine, oncologic, or orthopaedic disorders. Ferritin is a major acute-phase protein in dogs, increasing during inflammation; however, it could also be affected by other conditions, including trauma, iron metabolism dysregulations, neoplasia, or hypoxia. Higher ferritin levels have been reported in obese humans, but ferritin has not been explored in canine obesity. To evaluate the possible changes in serum ferritin in canine obesity, ferritin levels from lean/normal weight (CG, n = 55) and overweight/obese dogs (OG, n = 37) were measured, together with complete hemogram and biochemical analyses. Statistically significant higher ferritin levels (1.2-fold) were found in OG (median, (interquartile range), 204 (166–227.5) µg/L) in comparison to CG animals (172 (137–210) µg/L)), with median levels of ferritin in OG dogs above the reference range for healthy animals in our laboratory (60–190 µg/L). In addition, statistically significant higher mean corpuscular volume (MCV), mean cell haemoglobin concentration (MCHC), total proteins, globulins, haptoglobin, total ferric fixation capacity (TIBC), alkaline phosphatase (ALP), butyrylcholinesterase (BChE), triglycerides, and calcium were observed in OG in comparison to CG. The higher levels in ferritin, together with higher TBIC, haematocrit, and MCV, could indicate tissue hypoxia in obese dogs.
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Citation
Veterinary Sciences, 2023, Vol. 10 (7) : 457
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/