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Serum ferritin in obese dogs: changes and comparison with other analytes

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dc.contributor.authorFranco Martínez, Lorena
dc.contributor.authorPardo Marín, Luis
dc.contributor.authorSánchez Mateos, Laura
dc.contributor.authorMuñoz Prieto, Alberto
dc.contributor.authorGarcía Martínez, Juan Diego
dc.contributor.authorCerón, José J.
dc.contributor.authorMartínez Subiela, Silvia
dc.contributor.authorRubio, Camila P.
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-01-30T12:17:19Z
dc.date.available2025-01-30T12:17:19Z
dc.date.issued2023-07-11
dc.description© 2023 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Veterinary Sciences. To access the final edited and published work see https://doi.org/10.3390/vetsci10070457es
dc.description.abstractCanine obesity is the most common nutritional disorder and is associated with decreased quality of life and longevity as well as comorbidities including cardiorespiratory, endocrine, oncologic, or orthopaedic disorders. Ferritin is a major acute-phase protein in dogs, increasing during inflammation; however, it could also be affected by other conditions, including trauma, iron metabolism dysregulations, neoplasia, or hypoxia. Higher ferritin levels have been reported in obese humans, but ferritin has not been explored in canine obesity. To evaluate the possible changes in serum ferritin in canine obesity, ferritin levels from lean/normal weight (CG, n = 55) and overweight/obese dogs (OG, n = 37) were measured, together with complete hemogram and biochemical analyses. Statistically significant higher ferritin levels (1.2-fold) were found in OG (median, (interquartile range), 204 (166–227.5) µg/L) in comparison to CG animals (172 (137–210) µg/L)), with median levels of ferritin in OG dogs above the reference range for healthy animals in our laboratory (60–190 µg/L). In addition, statistically significant higher mean corpuscular volume (MCV), mean cell haemoglobin concentration (MCHC), total proteins, globulins, haptoglobin, total ferric fixation capacity (TIBC), alkaline phosphatase (ALP), butyrylcholinesterase (BChE), triglycerides, and calcium were observed in OG in comparison to CG. The higher levels in ferritin, together with higher TBIC, haematocrit, and MCV, could indicate tissue hypoxia in obese dogs.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationVeterinary Sciences, 2023, Vol. 10 (7) : 457
dc.identifier.doihttps://doi.org/10.3390/vetsci10070457
dc.identifier.issnElectronic: 2306-7381
dc.identifier.urihttp://hdl.handle.net/10201/149755
dc.languageenges
dc.publisherMDPIes
dc.relationL.F.-M. was granted a Margarita Salas postdoctoral contract 107144/2022 by the Ministerio de Universidades of the Government of Spain, financed by the European Union—Next Generation EU. AMP and CPR have a post-doctoral fellowship “Ramón y Cajal” supported by the Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación (AEI), Spain, and The European Next Generation Funds (Next Generation EU) (RYC2021-033660-I and RYC2021-034764-I, respectively).es
dc.relation.publisherversionhttps://www.mdpi.com/2306-7381/10/7/457es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAcute phase proteinses
dc.subjectBiomarkerses
dc.subjectCanine obesityes
dc.subjectDoges
dc.subjectFerritines
dc.subjectHypoxiaes
dc.subjectInflammationes
dc.titleSerum ferritin in obese dogs: changes and comparison with other analyteses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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