Publication: Platelet-generated amyloid beta peptides
in Alzheimer’s disease and glaucoma
Authors
Inyushin, Mikhail ; Zayas Santiago, Astrid ; Rojas, Legier ; Kucheryavykh, Yuri ; Kucheryavykh, Lilia
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-18-111
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info:eu-repo/semantics/article
Description
Abstract
Amyloid beta (Aβ) peptides have been
implicated in both Alzheimer’s disease (AD) and
glaucoma and have been shown to be the key etiological
factor in these dangerous health complications. On the
other hand, it is well known that Aβ peptide can be
generated from its precursor protein and massively
released from the blood to nearby tissue upon the
activation of platelets due to their involvement in innate
immunity and inflammation processes. Here we review
evidence about the development of AD and glaucoma
neuronal damage showing their dependence on platelet
count and activation. The correlation between the effect
on platelet count and the effectiveness of anti-AD and
anti-glaucoma therapies suggest that platelets may be an
important player in these diseases.
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Citation
Histology and Histopathology, Vol.34, nº8, (2019)
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