Publication:
Platelet-generated amyloid beta peptides in Alzheimer’s disease and glaucoma

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dc.contributor.authorInyushin, Mikhail
dc.contributor.authorZayas Santiago, Astrid
dc.contributor.authorRojas, Legier
dc.contributor.authorKucheryavykh, Yuri
dc.contributor.authorKucheryavykh, Lilia
dc.date.accessioned2022-07-06T08:38:57Z
dc.date.available2022-07-06T08:38:57Z
dc.date.issued2019
dc.description.abstractAmyloid beta (Aβ) peptides have been implicated in both Alzheimer’s disease (AD) and glaucoma and have been shown to be the key etiological factor in these dangerous health complications. On the other hand, it is well known that Aβ peptide can be generated from its precursor protein and massively released from the blood to nearby tissue upon the activation of platelets due to their involvement in innate immunity and inflammation processes. Here we review evidence about the development of AD and glaucoma neuronal damage showing their dependence on platelet count and activation. The correlation between the effect on platelet count and the effectiveness of anti-AD and anti-glaucoma therapies suggest that platelets may be an important player in these diseases.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.citationHistology and Histopathology, Vol.34, nº8, (2019)
dc.identifier.doiDOI: 10.14670/HH-18-111
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/122144
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBeta-amyloid peptidees
dc.subjectAlzheimer’ses
dc.subjectGlaucomaes
dc.subjectPlateletses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePlatelet-generated amyloid beta peptides in Alzheimer’s disease and glaucomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nº8 (2019)