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PTK7 expression is associated with lymph node metastasis, ALK and EGFR mutations in lung adenocarcinomas

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dc.contributor.authorJiang, Wei
dc.contributor.authorHe, Jing
dc.contributor.authorLv, Bihong
dc.contributor.authorXi, Xiaoxiang
dc.contributor.authorHe, Guangming
dc.contributor.authorHe, Jingkang
dc.date.accessioned2022-11-21T16:46:22Z
dc.date.available2022-11-21T16:46:22Z
dc.date.issued2020
dc.description.abstractNon-small cell lung cancer (NSCLC) is one of the leading causes of cancer death worldwide. Lung adenocarcinoma is the main tumor type of NSCLC. Recent advances in the molecular characterization and personalized therapies have improved NSCLC patient prognosis. Previous studies showed that protein tyrosine kinase 7 (PTK7) plays an important role in human cancers. However, the role of PTK7 has not been investigated. PTK7 expression was assessed by immunohistochemistry in 95 patients with lung adenocarcinoma. Correlations of PTK7 expression levels with clinicopathological parameters, EGFR mutation and EML4-ALK fusion were examined. Positive PTK7 expression was detected in 47.4% of lung adeno- carcinoma. PTK7 expression was associated with gender (P=0.024), lymph node metastasis (P<0.001), ALK mutation (P=0.050), and EGFR mutations (P=0.014). No significant association was found between PTK7 expression and age (P=0.831), differentiation (P=0.494), adenocarcinoma subtype (P=0.098) and Ki67 (P=0.473). Our data suggest that PTK7 plays an oncogenic role in lung adenocarcinoma and may be a molecular marker for lymph node metastasis.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and Histopathology Vol. 35, nº5 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-183
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/125792
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPTK7es
dc.subjectLung adenocarcinomaes
dc.subjectMetastasises
dc.subjectEML4-ALKes
dc.subjectEGFR mutationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePTK7 expression is associated with lymph node metastasis, ALK and EGFR mutations in lung adenocarcinomases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº5 (2020)