Publication: PTK7 expression is associated with lymph node metastasis, ALK and EGFR mutations in lung adenocarcinomas
Authors
Jiang, Wei ; He, Jing ; Lv, Bihong ; Xi, Xiaoxiang ; He, Guangming ; He, Jingkang
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-183
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Non-small cell lung cancer (NSCLC) is one
of the leading causes of cancer death worldwide. Lung
adenocarcinoma is the main tumor type of NSCLC.
Recent advances in the molecular characterization and
personalized therapies have improved NSCLC patient
prognosis. Previous studies showed that protein tyrosine
kinase 7 (PTK7) plays an important role in human
cancers. However, the role of PTK7 has not been
investigated. PTK7 expression was assessed by
immunohistochemistry in 95 patients with lung
adenocarcinoma. Correlations of PTK7 expression levels
with clinicopathological parameters, EGFR mutation and
EML4-ALK fusion were examined. Positive PTK7
expression was detected in 47.4% of lung adeno-
carcinoma. PTK7 expression was associated with gender
(P=0.024), lymph node metastasis (P<0.001), ALK
mutation (P=0.050), and EGFR mutations (P=0.014). No
significant association was found between PTK7
expression and age (P=0.831), differentiation (P=0.494),
adenocarcinoma subtype (P=0.098) and Ki67 (P=0.473).
Our data suggest that PTK7 plays an oncogenic role in
lung adenocarcinoma and may be a molecular marker for
lymph node metastasis.
publication.page.subject
Citation
Histology and Histopathology Vol. 35, nº5 (2020)
item.page.embargo
Ir a EstadÃsticas
Este Ãtem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/