Publication: The inhibitory effect of flavonoids and their gut-derived metabolites on the replication of Chlamydia abortus in the AH-1 ovine trophoblast cell line.
Authors
Del Río, Laura ; Salinas, Jesús ; García-Conesa, María Teresa ; Buendía Marín, Antonio Julián
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Publisher
Elsevier Ltd.
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DOI
https://doi.org/10.1016/j.rvsc.2019.09.006
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info:eu-repo/semantics/article
Description
© 2019 Elsevier.
This document is the published version of a published work that appeared in final form in Research in Veterinary Scienc
To access the final work, see https://doi.org/10.1016/j.rvsc.2019.09.006
Abstract
The obligate intracellular bacterium Chlamydia abortus causes abortion and constitutes a worldwide threat for
livestock. Plant-derived flavonoids have antimicrobial effects against veterinary and human pathogens and may be of help in the fight against C. abortus. The anti-infective efficacy against C. abortus of the flavonoids apigenin and naringenin, and of four of their derived metabolites was explored using an in vitro model of ovine trophoblast cells. Overall, the anti-infective effectiveness was apigenin > naringenin > benzoic acid > 3-(4-
hydroxyphenyl) propionic acid~4-hydroxyphenyl acetic acid~4-hydroxybenzoic. At the lowest concentration
tested (10 μM), apigenin, naringenin and benzoic acid inhibited the formation of C. abortus inclusions by 80%,
67%, and 39%, respectively. The cytotoxicity and anti-proliferative effects on the trophoblast host cells also
differed greatly between the tested compounds. Our findings suggest that flavonoids may be of therapeutic value against C. abortus infection but metabolic conversion has a substantial and variable effect on their anti-chlamydial activity. Our results also support the notion that the mechanisms of anti-infective action may involve
combined effects of the compounds against the host cells and the bacteria.
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