Publication: Importance and Antimicrobial Resistance of Mycoplasma bovis in Clinical Respiratory Disease in Feedlot Calves
Authors
García Galán, Ana ; Gómez Martín, Ángel ; Ortega, Joaquín ; Rodríguez, Francisco ; García Muñoz, Angel ; Fé Rodríguez, Christian de la ; Seva Alcaraz, Juan
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Publisher
MDPI
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DOI
https://doi.org/ 10.3390/ani11051470
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info:eu-repo/semantics/article
Description
©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published, version of a Published Work that appeared in final form in Animals. To access the final edited and published work see https://doi.org/ 10.3390/ani11051470
Abstract
Bovine respiratory disease (BRD) is an important viral and/or bacterial disease that mainly
affects feedlot calves. The involvement of Mycoplasma bovis in BRD can lead to chronic pneumonia
poorly responsive to antimicrobial treatment. Caseonecrotic bronchopneumonia is a pulmonary
lesion typically associated with M. bovis. In Spain, M. bovis is widely distributed in the feedlots and
circulating isolates are resistant to most antimicrobials in vitro. However, the role of this species
in clinical respiratory disease of feedlot calves remains unknown. Furthermore, available data are
relative to a fixed panel of antimicrobials commonly used to treat BRD, but not to the specific set
of antimicrobials that have been used for treating each animal. This study examined 23 feedlot
calves raised in southeast Spain (2016–2019) with clinical signs of respiratory disease unresponsive to
treatment. The presence of M. bovis was investigated through bacteriology (culture and subsequent
PCR), histopathology and immunohistochemistry. The pathogen was found in 86.9% (20/23) of
the calves, mainly in the lungs (78.26%; 18/23). Immunohistochemistry revealed M. bovis antigens
in 73.9% (17/23) of the calves in which caseonecrotic bronchopneumonia was the most frequent
lesion (16/17). Minimum inhibitory concentration assays confirmed the resistance of a selection of 12
isolates to most of the antimicrobials specifically used for treating the animals in vivo. These results
stress the importance of M. bovis in the BRD affecting feedlot calves in Spain
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