Importance and Antimicrobial Resistance of Mycoplasma bovis in Clinical Respiratory Disease in Feedlot Calves

García Galán, Ana; Gómez Martín, Ángel; Ortega, Joaquín; Rodríguez, Francisco; García Muñoz, Angel; Fé Rodríguez, Christian de la; Seva Alcaraz, Juan

Publication:
Importance and Antimicrobial Resistance of Mycoplasma bovis in Clinical Respiratory Disease in Feedlot Calves

dc.contributor.author	García Galán, Ana
dc.contributor.author	Gómez Martín, Ángel
dc.contributor.author	Ortega, Joaquín
dc.contributor.author	Rodríguez, Francisco
dc.contributor.author	García Muñoz, Angel
dc.contributor.author	Fé Rodríguez, Christian de la
dc.contributor.author	Seva Alcaraz, Juan
dc.contributor.department	Sanidad Animal
dc.date.accessioned	2023-12-22T08:58:26Z
dc.date.available	2023-12-22T08:58:26Z
dc.date.issued	2021-05-20
dc.description	©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published, version of a Published Work that appeared in final form in Animals. To access the final edited and published work see https://doi.org/ 10.3390/ani11051470	es
dc.description.abstract	Bovine respiratory disease (BRD) is an important viral and/or bacterial disease that mainly affects feedlot calves. The involvement of Mycoplasma bovis in BRD can lead to chronic pneumonia poorly responsive to antimicrobial treatment. Caseonecrotic bronchopneumonia is a pulmonary lesion typically associated with M. bovis. In Spain, M. bovis is widely distributed in the feedlots and circulating isolates are resistant to most antimicrobials in vitro. However, the role of this species in clinical respiratory disease of feedlot calves remains unknown. Furthermore, available data are relative to a fixed panel of antimicrobials commonly used to treat BRD, but not to the specific set of antimicrobials that have been used for treating each animal. This study examined 23 feedlot calves raised in southeast Spain (2016–2019) with clinical signs of respiratory disease unresponsive to treatment. The presence of M. bovis was investigated through bacteriology (culture and subsequent PCR), histopathology and immunohistochemistry. The pathogen was found in 86.9% (20/23) of the calves, mainly in the lungs (78.26%; 18/23). Immunohistochemistry revealed M. bovis antigens in 73.9% (17/23) of the calves in which caseonecrotic bronchopneumonia was the most frequent lesion (16/17). Minimum inhibitory concentration assays confirmed the resistance of a selection of 12 isolates to most of the antimicrobials specifically used for treating the animals in vivo. These results stress the importance of M. bovis in the BRD affecting feedlot calves in Spain	es
dc.format	application/pdf	es
dc.format.extent	14	es
dc.identifier.doi	https://doi.org/ 10.3390/ani11051470
dc.identifier.eisbn	Animals 2021, 11, 1470	es
dc.identifier.issn	2076-2615
dc.identifier.uri	http://hdl.handle.net/10201/136866
dc.language	eng	es
dc.publisher	MDPI	es
dc.relation	This research was funded by the Spanish Ministry of Economy and Competitiveness (Spanish Government) co-financed by FEDER funds, project AGL2016-76568-R.	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Mycoplasma bovis	es
dc.subject	Pneumonia	es
dc.subject	Antimicrobial resistance	es
dc.subject	Feedlot calves	es
dc.subject	Minimum inhibitory concentration	es
dc.title	Importance and Antimicrobial Resistance of Mycoplasma bovis in Clinical Respiratory Disease in Feedlot Calves	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
relation.isAuthorOfPublication	f4f4c0d0-67f8-43f4-afa3-7bf3d0f3c03a
relation.isAuthorOfPublication.latestForDiscovery	f4f4c0d0-67f8-43f4-afa3-7bf3d0f3c03a