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Morphological and biochemical alterations in growing rats induced by etretinate

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dc.contributor.authorAmo Bernal, C.es
dc.contributor.authorMendez Sanchez, A.es
dc.contributor.authorSinisterra Gago, J.V.
dc.contributor.authorSierra Plana, M.A.
dc.contributor.authorFuentes Garcia, A.
dc.date.accessioned2011-02-22T10:29:17Z
dc.date.available2011-02-22T10:29:17Z
dc.date.issued1989
dc.description.abstractEtretinate is an aromatic retinoid extensively used on Dermatology. Its toxic effects, however, reduce its application from a clinical point of view. In the present paper, we study etretinate intoxication of 48 growing Wistar rats. The intoxication was for 12 weeks using etretinate doses of 0.5 and 6 (mglkg) / day. The concentrations of etretinate in plasma and liver were determined. Total seric cholesterol and triglyceride concentrations were analyzed. Structural and ultrastructural histological studies of liver samples were carried out. Continuous etretinate ingestions seem to produce an alteration in the detoxication of enzymatic complexes in the growing rats with both the concentrations, due to the increase in etretinate blood plasma observed during the study. There is a relationship between the etretinate dose and its blood plasma concentration and toxic effect, but there is not with etretinate concentration in the liver. The blood plasma concentration of cholesterol and triglycerides is not related to histological liver lesions. The histological study confirms hepatotoxicity with both doses. Nevertheless, the anatomopathological lesions observed do not seem to be related to the blood plasma and liver etretinate concentrations.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18686
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMorphologyes
dc.subjectEtretinatees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleMorphological and biochemical alterations in growing rats induced by etretinatees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 4, nº 4 (1989)