Publication: Morphological and biochemical alterations in growing rats induced by etretinate
Loading...
Date
1989
Authors
Amo Bernal, C. ; Mendez Sanchez, A. ; Sinisterra Gago, J.V. ; Sierra Plana, M.A. ; Fuentes Garcia, A.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Etretinate is an aromatic retinoid extensively
used on Dermatology. Its toxic effects, however,
reduce its application from a clinical point of view. In the
present paper, we study etretinate intoxication of 48
growing Wistar rats. The intoxication was for 12 weeks
using etretinate doses of 0.5 and 6 (mglkg) / day. The
concentrations of etretinate in plasma and liver were
determined.
Total seric cholesterol and triglyceride concentrations
were analyzed. Structural and ultrastructural histological
studies of liver samples were carried out. Continuous
etretinate ingestions seem to produce an alteration in the
detoxication of enzymatic complexes in the growing rats
with both the concentrations, due to the increase in
etretinate blood plasma observed during the study.
There is a relationship between the etretinate dose and
its blood plasma concentration and toxic effect, but there
is not with etretinate concentration in the liver. The
blood plasma concentration of cholesterol and triglycerides
is not related to histological liver lesions.
The histological study confirms hepatotoxicity with
both doses. Nevertheless, the anatomopathological lesions
observed do not seem to be related to the blood
plasma and liver etretinate concentrations.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.