Publication: Distribution of DMT 1 within the human glandular system
Authors
Koch, R.O. ; Zoller, H. ; Theurl, I. ; Obrist, P. ; Egg, G. ; Strohmayer, W. ; Vogel, W. ; Weiss, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Background & Aims: DMT1 is a
transmembrane protein which transports the divalent
metal ions Fe2+, Zn2+, Cu2+ and Mn2+. Although DMT1
has been functionally linked to duodenal absorption and
cellular utilisation of iron hardly anything is known
about its distribution and potential role within the human
glandular system. Methods: Two polyclonal antibodies
were raised to study the expression of DMT1 in tissues
obtained from human corpus by the means of
immunocytochemistry and Western blotting. Results: All
antibodies specifically detected a 60 kD protein band
referring to human DMT1. Significant amounts of
DMT1 expression were detected on the luminal site of
organs, which are involved in excretion/re-absorption
processes, such as salivary glands, pancreas, biliary tract
and gallbladder. Conclusions: Our results suggest that
DMT1 may be of pivotal importance for the regulation
of metal ion homeostasis within organs involved in
absorption and excretion of ions.
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