DigitalUM :: Browsing by Subject "Glandulae"

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Open Access
Distribution of DMT 1 within the human glandular system
(Murcia : F. Hernández, 2003) Koch, R.O.; Zoller, H.; Theurl, I.; Obrist, P.; Egg, G.; Strohmayer, W.; Vogel, W.; Weiss, G.
Background & Aims: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+. Although DMT1 has been functionally linked to duodenal absorption and cellular utilisation of iron hardly anything is known about its distribution and potential role within the human glandular system. Methods: Two polyclonal antibodies were raised to study the expression of DMT1 in tissues obtained from human corpus by the means of immunocytochemistry and Western blotting. Results: All antibodies specifically detected a 60 kD protein band referring to human DMT1. Significant amounts of DMT1 expression were detected on the luminal site of organs, which are involved in excretion/re-absorption processes, such as salivary glands, pancreas, biliary tract and gallbladder. Conclusions: Our results suggest that DMT1 may be of pivotal importance for the regulation of metal ion homeostasis within organs involved in absorption and excretion of ions.