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Distribution of DMT 1 within the human glandular system

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dc.contributor.authorKoch, R.O.es
dc.contributor.authorZoller, H.es
dc.contributor.authorTheurl, I.
dc.contributor.authorObrist, P.
dc.contributor.authorEgg, G.
dc.contributor.authorStrohmayer, W.
dc.contributor.authorVogel, W.
dc.contributor.authorWeiss, G.
dc.date.accessioned2011-06-08T09:03:55Z
dc.date.available2011-06-08T09:03:55Z
dc.date.issued2003
dc.description.abstractBackground & Aims: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+. Although DMT1 has been functionally linked to duodenal absorption and cellular utilisation of iron hardly anything is known about its distribution and potential role within the human glandular system. Methods: Two polyclonal antibodies were raised to study the expression of DMT1 in tissues obtained from human corpus by the means of immunocytochemistry and Western blotting. Results: All antibodies specifically detected a 60 kD protein band referring to human DMT1. Significant amounts of DMT1 expression were detected on the luminal site of organs, which are involved in excretion/re-absorption processes, such as salivary glands, pancreas, biliary tract and gallbladder. Conclusions: Our results suggest that DMT1 may be of pivotal importance for the regulation of metal ion homeostasis within organs involved in absorption and excretion of ions.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21479
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectGlandulaees
dc.subjectPancreases
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleDistribution of DMT 1 within the human glandular systemes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.18, nº 4 (2003)