Publication: A comparative pathological study of three strains of Trypanosoma cruzi in an experimental model
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Date
1991
Authors
De Diego, J.A. ; Penin, P. ; Del Rey, J. ; Mayer, R. ; Gamallo, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Trypanosoma cruzi. the etiological agent of
Chaps' cliscase. shows a wide variation in its biological
hcl ia\ . io~~dre pending on the geographical distribution
of different strains. Moreover. sonic. strains can show;
variations with the course of tinic. We have studied the
tissular tropism of three strains of T. cruzi, Cali. Buli\,ia
and Y. from different geographical origins (Colombia.
Bolivia ancl I3rasil respectively) on Swiss inice in order
to detect any pnrsihle modification in their behaviour
attributable only to parasite but not to host variations.
The anatoniopathological stud!! of sections from
heart. brain. liver. spleen. lymphatic ganglion. skeletal
muscle and colon from Swiss mice infected with these
strains has cvidencecl the presence of some important
tliscrcpancics hctwecn the tissular tropism expected
from thcir former clescriptions. and classical typification
and then observed lesions. The greatest variations were
found in the Y strain which had been described as
eniincntly I-eticulotropic but presented lesions in all the
organs except tlie spleen and lymphatic ganglion. We
consider that the x~ariationsf ound in our study can only
be explained in ternis of changes in the properties of
the strains consiclercd. and conclude that the classic
typificrrtion techniques based on the constant! of the
characteristics of the parasite are not fully reliable
for the description and clinical management of some
evolving strains.
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