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Distribution of immunoreactive transforming growth factor-alpha in non-neoplastic human salivary glands

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dc.contributor.authorOgbureke, K.U.E.es
dc.contributor.authorMacDaiel, R.K.es
dc.contributor.authorJacob, R.S.
dc.contributor.authorDurban, E.M.
dc.date.accessioned2011-02-22T10:30:38Z
dc.date.available2011-02-22T10:30:38Z
dc.date.issued1995
dc.description.abstractThe distribution of immunoreactive transforming growth factor-alpha (TGF-a) was studied in non-neoplastic human major and minor salivary glands using an immunoperoxidase assay in conjuction with an antiserum to human TGF-a. The ductal cell components of all major and minor salivary glands were found to contain significant amounts of TGF-a immunoreactivity. In contrast, acinar and myoepithelial cells consistently lacked immune reaction product in both types of glands. Occasionally, an asynchronous pattern of TGF-a ductal cell immunoreactivity was observed in specific ducts within a section. Also, intraductal secretions, when present, were found to contain TGF-a immunoreactive material. Ductal cells and connective tissue from salivary glands samples showing significant lymphocytic infiltration and loss of acinar cells exhibited higher levels of TGF-a immunoreactivity than normal salivary gland samples. These observations demonstrate, for the first time, the presence of TGF-a immunoreactivity in specific structural components of non-neoplastic human major and minor salivary glands. It will be important in future studies to determine whether alterations in TGF-a expression are detectable in diverse types of salivary gland tumors.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18747
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectSalivary glandes
dc.subjectInmunocytochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.3 - Patología del aparato digestivo. Odontologíaes
dc.titleDistribution of immunoreactive transforming growth factor-alpha in non-neoplastic human salivary glandses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.10, nº 3 (1995)