Publication: Distribution of immunoreactive transforming growth factor-alpha in non-neoplastic human salivary glands
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Date
1995
Authors
Ogbureke, K.U.E. ; MacDaiel, R.K. ; Jacob, R.S. ; Durban, E.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The distribution of immunoreactive
transforming growth factor-alpha (TGF-a) was studied
in non-neoplastic human major and minor salivary
glands using an immunoperoxidase assay in conjuction
with an antiserum to human TGF-a. The ductal cell
components of all major and minor salivary glands were
found to contain significant amounts of TGF-a
immunoreactivity. In contrast, acinar and myoepithelial
cells consistently lacked immune reaction product in
both types of glands. Occasionally, an asynchronous
pattern of TGF-a ductal cell immunoreactivity was
observed in specific ducts within a section. Also,
intraductal secretions, when present, were found to
contain TGF-a immunoreactive material. Ductal cells
and connective tissue from salivary glands samples
showing significant lymphocytic infiltration and loss of
acinar cells exhibited higher levels of TGF-a
immunoreactivity than normal salivary gland samples.
These observations demonstrate, for the first time, the
presence of TGF-a immunoreactivity in specific
structural components of non-neoplastic human major
and minor salivary glands. It will be important in future
studies to determine whether alterations in TGF-a
expression are detectable in diverse types of salivary
gland tumors.
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