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Mucoepidermoid tumors of the bronchus. Ultrastructural and immunohistochemical study. Histiogenic correlations

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dc.contributor.authorSánchez-Mora, N.es
dc.contributor.authorParra-Blanco, V.es
dc.contributor.authorCebollero-Presmanes, M.
dc.contributor.authorCarretero-Albiñana, L.
dc.contributor.authorHerranz, M.L.
dc.contributor.authorÁlvarez-Fernández, E.
dc.date.accessioned2012-05-21T12:08:17Z
dc.date.available2012-05-21T12:08:17Z
dc.date.issued2007
dc.description.abstractBronchial mucoepidermoid tumors are uncommon neoplasms, morphologically similar to their salivary gland counterpart. The histogenesis is controversial. The aim of this study is to identify myoepithelial cells and speculate on their role in the origin of these tumors. Methods and Results: Sixteen bronchial mucoepidermoid tumor surgical specimens were formalin-fixed, paraffin-embedded and studied using a panel of nine antibodies in order to identify a myoepithelial differentiation. Additional antigens against several cytokeratins were performed in four cases and five of the biopies were studied using the electron microscopy. The different types of cells of the primary bronchial mucoepidermoid tumor (mucous luminal, intermediate and squamous) reacted strongly against AE1, CK7, 34bE12 and weakly with AE3, CK18 and CK8/18/19. S-100, a-smooth muscle actin, muscle actin HHF35 and a-actinin were consistently negative in all cell types. CD10 was positive in very few cells in just one case. Conclusion: The immunohistochemical and the ultrastructural study of bronchial mucoepidermiod tumors support a ductal unit origin, without a myoepithelial participation.es
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dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27531
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemicales
dc.subjectBronchial glandses
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleMucoepidermoid tumors of the bronchus. Ultrastructural and immunohistochemical study. Histiogenic correlationses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº 1 (2007)