Publication: Mucoepidermoid tumors of the bronchus.
Ultrastructural and immunohistochemical study.
Histiogenic correlations
Authors
Sánchez-Mora, N. ; Parra-Blanco, V. ; Cebollero-Presmanes, M. ; Carretero-Albiñana, L. ; Herranz, M.L. ; Álvarez-Fernández, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Bronchial mucoepidermoid tumors are
uncommon neoplasms, morphologically similar to their
salivary gland counterpart. The histogenesis is
controversial. The aim of this study is to identify
myoepithelial cells and speculate on their role in the
origin of these tumors. Methods and Results: Sixteen
bronchial mucoepidermoid tumor surgical specimens
were formalin-fixed, paraffin-embedded and studied
using a panel of nine antibodies in order to identify a
myoepithelial differentiation. Additional antigens against
several cytokeratins were performed in four cases and
five of the biopies were studied using the electron
microscopy. The different types of cells of the primary
bronchial mucoepidermoid tumor (mucous luminal,
intermediate and squamous) reacted strongly against
AE1, CK7, 34bE12 and weakly with AE3, CK18 and CK8/18/19. S-100, a-smooth muscle actin, muscle actin
HHF35 and a-actinin were consistently negative in all
cell types. CD10 was positive in very few cells in just
one case. Conclusion: The immunohistochemical and the
ultrastructural study of bronchial mucoepidermiod
tumors support a ductal unit origin, without a
myoepithelial participation.
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